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Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.
Circ Genom Precis Med
8
2018
Adverse Ventricular Remodeling, Human, PKC, PKC-, PKC- transcript, PKC--, PKC--lowering allele, PRKCA, PRKCA enhancer, cardiac and noncardiac cells, cardiac-specific enhancer, dilated cardiomyopathy, enhancer, expression quantitative trait locus, forward strand minor allele, heart disease, human, human tissues, humans, intron 2, left, patients, protein kinase C, rs9912468, rs9912468 PKC--lowering allele, zebrafish
Author NameAffiliation
Nathan R TuckerFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Victoria A ParsonsFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Monika StollFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
François CambienFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Honghuang LinFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Nicholas L SmithFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Nicholas L SmithFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Ramachandran S VasanFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Pim van der HarstFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Christopher Newton-ChehFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Jin LiFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Cecilia E KimFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Hakon HakonarsonFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Hakon HakonarsonFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Euan A AshleyFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Patrick T EllinorFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Patrick T EllinorFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Kenneth B MarguliesFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
Kenneth B MarguliesFrom the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, T.P.C.) Cardiovascular Research Center (N.R.T., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, University of Illinois at Urbana-Champaign (S.D.Z.) Heidelberg University Hospital, Institute of Human Genetics, University of Munster, M.S.) INSERM UMRS6-IACN, Boston University School of Medicine, University of Washington, University Medical Center Rotterdam, the Netherlands (J.F.F.) Boston University School of Medicine, University of Groningen, University Medical Center Groningen, Broad Institute, MA (C.N.-C.) Center for Applied Genomics, Children's Hospital of Philadelphia, H.H.) Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.) Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Cleveland Clinic, W.H.W.T.) and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center
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