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Paper Details

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry.
J Biol Chem
6
2023
AKT, FAK, Focal adhesion kinase, G protein-coupled receptors, G proteins, GNA11, GNAQ, GNAQ-mutant UM cells, Gq, Gq proteins, Gq-driven malignancies, PI3K, UM, UM cells, driver oncogenes, focal adhesion kinase, p85 regulatory subunit, tyrosine, uveal melanoma
Carcinogenesis, Clustered Regularly Interspaced Short Palindromic Repeats, Focal Adhesion Protein-Tyrosine Kinases, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Humans, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction
Author NameAffiliation
Nadia ArangUniversity of California San Diego, Moores Cancer Center, USA University of California San Diego
Simone LubranoUniversity of California San Diego, Moores Cancer Center, USA Department of Pharmacy, University of Pisa
Damiano Cosimo RigiraccioloUniversity of California San Diego, Moores Cancer Center
Daniela NachmansonUniversity of California San Diego
Scott M LippmanUniversity of California San Diego, Moores Cancer Center
Prashant Mali (CM4AI)University of California San Diego
Olivier HarismendyUniversity of California San Diego, Moores Cancer Center
Jorge Silvio GutkindUniversity of California San Diego, Moores Cancer Center
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