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Paper Details

Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.
Nat Med
57
2023
DNX, DNX-2401, anti-PD-1, glioblastoma, immune cell, patients, pembrolizumab, recurrent, recurrent glioblastoma, tumoral
Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Glioblastoma, Humans, Neoplasm Recurrence, Local, Oncolytic Virotherapy, Oncolytic Viruses
Author NameAffiliation
Farshad NassiriUniversity of Toronto
Farshad NassiriPrincess Margaret Cancer Center, University Health Network
Vikas PatilPrincess Margaret Cancer Center, University Health Network
Leeor S YefetPrincess Margaret Cancer Center, University Health Network
Olivia SinghPrincess Margaret Cancer Center, University Health Network
Jeff LiuPrincess Margaret Cancer Center, University Health Network
Rachel M A DangUniversity of California Los Angeles
Takafumi N YamaguchiUniversity of California Los Angeles
Mariza DarasUniversity of California San Francisco
Timothy F Cloughesyuniversity of california los angeles Neuro-Oncology Program, David Geffen School of Medicine, University of California Los Angeles
Timothy F Cloughesyuniversity of california los angeles Neuro-Oncology Program, David Geffen School of Medicine, University of California Los Angeles
Howard ColmanHuntsman Cancer Institute and Department of Neurosurgery, University of Utah
Howard ColmanHuntsman Cancer Institute and Department of Neurosurgery, University of Utah
Priya KumthekarNorthwestern University Feinberg School of Medicine
Clark C ChenUniversity of Minnesota
Robert AikenRutgers Cancer Institute of New Jersey, Rutgers University
Morris D Groves
Shirley Ongthe Ohio State University Wexner Medical Center
Rohan RamakrishnaWeill Cornell Medical College, New York Presbyterian Hospital
Michael A VogelbaumMoffitt Cancer Center
Simon KhagiUniversity of North Carolina at Chapel Hill
Thomas J KaleyMemorial Sloan Kettering Cancer Center
Jason M MelearBaylor University Medical Center
David M PeereboomThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic
Analiz RodriguezUniversity of Arkansas for Medical Sciences
Maxim YankelevichUniversity of Michigan, Ann Arbor Beaumont Children's Hospital
Suresh NairLehigh Valley Topper Cancer Institute
Vinay K PuduvalliThe University of Texas MD Anderson Cancer Center
Kenneth AldapeNational Cancer Institute
Kenneth AldapeNational Cancer Institute
Andrew GaoUniversity Health Network
??lvaro L??pez-JaneiroClinica Universidad de Navarra
??lvaro L??pez-JaneiroNavarra Institute for Health Research (IdISNA)
Carlos E de AndreaClinica Universidad de Navarra
Carlos E de AndreaNavarra Institute for Health Research (IdISNA)
Marta M AlonsoNavarra Institute for Health Research (IdISNA)
Marta M AlonsoCenter for the Applied Medical Research (CIMA)
Marta M AlonsoClinica Universidad de Navarra
Marta M AlonsoNavarra Institute for Health Research (IdISNA)
Marta M AlonsoClinica Universidad de Navarra
Marta M AlonsoCenter for the Applied Medical Research (CIMA)
Paul C BoutrosUniversity of California Los Angeles
Joan M RobbinsDNATrix Inc.
Warren P MasonPrincess Margaret Cancer Center, University Health Network
Adam M SonabendFeinberg School of Medicine, Northwestern University
Adam M SonabendNorthwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University
Roger StuppFeinberg School of Medicine, Northwestern University
Roger StuppNorthwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University
Roger StuppFeinberg School of Medicine, Northwestern University
Roger StuppFeinberg School of Medicine, Northwestern University
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ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link