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Paper Details

Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.
Nat Cancer
16
2022
DMG, DMG cells, DMGs, Diffuse midline gliomas, H3K27M, H3K27M gliomas, H3K27M mutant cells, H3K27M mutant glioma, H3K36me3, MAT2A, MAT2A protein, MTAP, amino acid, brain tumors, chromatin, epigenome, epigenomes, gliomas, histone 3 lysine 27, lysine, methionine, methionine adenosyltransferase 2A, mouse, short, tumors
Author NameAffiliation
Matthew E HalbertUniversity of Pittsburgh School of Medicine
Matthew E HalbertJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Apeng ChenUniversity of Pittsburgh School of Medicine
Apeng ChenLanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Apeng ChenJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Yijen L WuUniversity of Pittsburgh and Rangos Research Center Animal Imaging Core
Baoli HuUniversity of Pittsburgh School of Medicine
Baoli HuJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Gary KohanbashUniversity of Pittsburgh School of Medicine
Gary KohanbashJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Michael F MoranUniversity of Toronto
Jeremy N RichUniversity of Pittsburgh School of Medicine
Jeremy N RichUniversity of Pittsburgh School of Medicine
Robert M FriedlanderUniversity of Pittsburgh School of Medicine
Alberto BroniscerJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Alberto BroniscerUPMC Children's Hospital of Pittsburgh
Costas A LyssiotisUniversity of Michigan Medical School ann arbor
Nada JabadoMcGill University
Nada JabadoMcGill University, The Research Institute of the McGill University Health Center
Nada JabadoMcGill University
Nada JabadoMcGill University, The Research Institute of the McGill University Health Center
Ian F PollackUniversity of Pittsburgh School of Medicine
Ian F PollackJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Ian F PollackUniversity of Pittsburgh School of Medicine
Ian F PollackJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Stephen C MackBaylor College of Medicine, Dan L. Duncan Cancer Center
Stephen C MackSt Jude Children's Research Hospital
Stephen C MackBaylor College of Medicine, Dan L. Duncan Cancer Center
Stephen C MackSt Jude Children's Research Hospital
Sameer AgnihotriUniversity of Pittsburgh School of Medicine
Sameer AgnihotriJohn G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh
Sameer AgnihotriUniversity of Pittsburgh
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