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Paper Details

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
Proc Natl Acad Sci U S A
62
2014
7SK, 7SK small nuclear, 7SK snRNP, AF4, AFF1, Brd4, CDK9, CycT, CycT1, FMR2 family member 1, HIV, HIV-encoded transactivating (Tat) protein, P-TEFb, P-TEFb complexes, RNA polymerase, SEC, SECs, Tat, bromodomain protein 4, cyclin T, cyclin-dependent kinase 9, polymerase II, positive transcription elongation factor b, super elongation complexes
Alanine, Cell Cycle Proteins, Cell Nucleus, Cyclin T, Cyclin-Dependent Kinase 9, DNA-Binding Proteins, HeLa Cells, Humans, Nuclear Proteins, Positive Transcriptional Elongation Factor B, Protein Binding, Protein Structure, Tertiary, Ribonucleoproteins, Small Nuclear, Transcription Factors, Transcriptional Activation, Transcriptional Elongation Factors, tat Gene Products, Human Immunodeficiency Virus
Author NameAffiliation
Huasong LuSchool of Pharmaceutical Sciences, Innovation Center for Cell Biology, Xiamen University
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Release 1.2