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Paper Details

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Nat Commun
106
2020
ATP7A, CRC, Copper, KRAS, KRAS-mutated CRC, KRAS-mutated cells, KRAS-mutated neoplasms, cancers, colorectal cancer, colorectal cancers, copper, human, intestinal epithelial cells, mutant KRAS, neoplastic, oncogenic KRAS, therapeutic
Animals, Biological Availability, CRISPR-Cas Systems, Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Copper, Copper-Transporting ATPases, Female, Humans, Intestinal Mucosa, Mice, Mice, Knockout, Mice, Nude, Mice, SCID, Mutation, Proto-Oncogene Proteins p21(ras)
Author NameAffiliation
L??o AubertInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Neethi NandagopalInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Zachary SteinhartDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, College Street
Genevi??ve LavoieInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Sami Nourreddine (CM4AI)Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Jacob BermanLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, University Ave.
Marc K Saba-El-LeilInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
David PapadopoliLady Davis Institute for Medical Research, Jewish General Hospital, McGill University
Sichun LinDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, College Street
Traver HartMD Anderson Cancer Center, University of Texas
Graham MacLeodDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, College Street
Ivan TopisirovicLady Davis Institute for Medical Research, Jewish General Hospital, McGill University
Louis GabouryInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Louis GabouryUniversite de Montreal
Christoph J FahrniPetit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Daniel SchramekLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, University Ave.
Daniel SchramekUniversity of Toronto
Sylvain MelocheInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Sylvain MelocheUniversite de Montreal
Stephane AngersDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, College Street
Stephane AngersUniversity of Toronto
Philippe P RouxInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Philippe P RouxUniversite de Montreal
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