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Paper Details

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.
Clin Cancer Res
36
2020
AML, AZD4320, Bcl-2, Bcl-2 family members, Bcl-2 prosurvival proteins, Bcl-xL, Hematologic Cancer, Thrombocytopenia, Tumor, acute myeloid leukemia, cancer, cancers, in vitro cell, in vitro cell lines, patient, platelets, thrombocytopenia, tumor, tumor types, tumors, venetoclax
Animals, Antineoplastic Agents, Apoptosis, Benzamides, Cell Proliferation, Female, Hematologic Neoplasms, Humans, Mice, Mice, Inbred NOD, Mice, SCID, Piperidines, Proto-Oncogene Proteins c-bcl-2, Sulfones, Thrombocytopenia, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, bcl-X Protein
Author NameAffiliation
Srividya B BalachanderOncology R&D
Steven W CriscioneOncology R&D
Kate F BythOncology R&D
Justin CidadoOncology R&D
Ammar AdamOncology R&D
Terry MacIntyreOncology R&D
Shenghua WenOncology R&D
Deborah LawsonOncology R&D
Kathleen BurkeOncology R&D
Tristan J LubinskiOncology R&D
Jeffrey W TynerOncology R&D
Shannon K McWeeneyKnight Cancer Institute, Oregon Health and Science University
Jeffrey G VarnesKnight Cancer Institute, Oregon Health and Science University
Robert B DieboldOncology R&D
Thomas W GeroOncology R&D
Stephanos IoannidisOncology R&D
Edward J HennessyOncology R&D
William McCoullOncology R&D
Jamal C SaehOncology R&D
Paula LewisOncology R&D
Areya TabatabaiOncology R&D
Omid TavanaOncology R&D
Nancy Su
Alwin G SchullerOncology R&D
Mathew J GarnettWellcome Sanger Institute
Patricia JaaksWellcome Sanger Institute
Elizabeth A CokerWellcome Sanger Institute
Gareth P GregorySchool of Clinical Sciences at Monash Health, Monash University
Andrea NewboldPeter MacCallum Cancer Centre
Ricky W JohnstonePeter MacCallum Cancer Centre
Eric GanglOncology R&D
Martin WildOncology R&D
Michael ZindaOncology R&D
J Paul SecristOncology R&D
Barry R DaviesOncology R&D
Stephen FawellEarly Oncology R&D
Francis D GibbonsOncology R&D
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