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Paper Details

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
Nat Commun
9
2022
AP-1, BRAF, BRAF-mutated melanoma, CDK12, MAPK, Melanoma, NF-?, RAS, cyclin-dependent kinase 12, growth-promoting genes, long genes, melanoma, melanoma cells, melanomas, mitogen-activated protein kinase, multiple exons, short genes, skin cancer, transcriptional CDK
Cell Line, Tumor, Cyclin-Dependent Kinases, Humans, Melanoma, Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins B-raf, Skin Neoplasms
Author NameAffiliation
Thibault HoulesInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Genevi??ve LavoieInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Sami Nourreddine (CM4AI)Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Sami Nourreddine (CM4AI)University of California
Winnie CheungInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Eric VaillancourtInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
C??lia M Gu??rinInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Mathieu BouttierInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Benoit GrondinInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Benoit GrondinUniversite du Quebec a Montreal
Sichun LinUniversity of Toronto
Marc K Saba-El-LeilInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Stephane AngersUniversity of Toronto
Stephane AngersLeslie Dan Faculty of Pharmacy, University of Toronto
Stephane AngersUniversity of Toronto
Sylvain MelocheInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Sylvain MelocheUniversite de Montreal
Philippe P RouxInstitute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Philippe P RouxUniversite de Montreal
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