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Paper Details

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.
Genome Biol
118
2017
Ames dwarf, Ames dwarf Prop1 df/df mutation, CpG, CpG islands, DNA, Prop1, critical, dwarf, epigenome, gene regulatory regions, genome, highly expressed genes, histone, hypomethylated enhancers, liver cancer, mice, mouse, rapamycin, regulatory features, super-enhancers, whole
Aging, Animals, Cluster Analysis, CpG Islands, DNA Methylation, Dwarfism, Enhancer Elements, Genetic, Epigenesis, Genetic, Epigenomics, Female, Gene Expression Regulation, Liver, Longevity, Male, Mice, Organ Specificity, Regulatory Sequences, Nucleic Acid
Author NameAffiliation
John J ColeBeatson Institute for Cancer Research and University of Glasgow
Neil A RobertsonBeatson Institute for Cancer Research and University of Glasgow
Ghulam Mohammad RatherBeatson Institute for Cancer Research and University of Glasgow
John P ThomsonInstitute of Genetics and Molecular Medicine, Western General Hospital
Tony McBryanBeatson Institute for Cancer Research and University of Glasgow
Duncan SproulInstitute of Genetics and Molecular Medicine, Western General Hospital
Duncan SproulEdinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital
Tina WangUniversity of California San Diego
Claire BrockBeatson Institute for Cancer Research and University of Glasgow
William ClarkBeatson Institute for Cancer Research and University of Glasgow
Trey Ideker (CM4AI)University of California San Diego
Trey Ideker (CM4AI)University of California San Diego
Richard R MeehanInstitute of Genetics and Molecular Medicine, Western General Hospital
Richard A MillerDepartment of Pathology and Glenn Center for the Biology of Aging, University of Michigan ann arbor
Holly M Brown-BorgUniversity of North Dakota School of Medicine and Health Sciences
Peter D AdamsBeatson Institute for Cancer Research and University of Glasgow
Peter D AdamsSanford Burnham Prebys Medical Discovery Institute
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