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Paper Details

Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer.
N Engl J Med
398
2016
70-gene assay, Breast Cancer, Carboplatin, HER2, HER2-, PARP, Patients, Veliparib, biomarker, breast cancer, cancer, cancer subtypes, cancers, carboplatin, human epidermal growth factor receptor 2, patient, patients, poly(ADP-ribose), poly(ADP-ribose) polymerase, stage II or III, triple-negative breast cancer, triple-negative population, veliparib, women
Author NameAffiliation
Christina YauFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Christina YauFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Laura J Van't VeerFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Michael HogarthFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Melissa PaoloniFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Melissa PaoloniFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
William F SymmansFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Judy C BougheyFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Minetta C LiuFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Claudine IsaacsFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Lajos PusztaiFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Rita NandaFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Richard B SchwabFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
Donald A BerryFrom University of California, Buck Institute for Research and Aging, University of California, University of California San Diego, and University of Southern California, Los Angeles (D.T.) - all in California University of Chicago (O.I.O., and Loyola University (K.S.A.), Chicago University of Pennsylvania, MI (J.P.) University of Texas M.D. Anderson Cancer Center, UT Southwestern Medical Center, D.A.B.) - all in Texas University of Minnesota, and Mayo Clinic, T.C.H.) - both in Minnesota Swedish Medical Center, Seattle (H.G.K.) Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Kansas, Lawrence (Q.J.K.) University of Arizona, Scottsdale (D.W.N.) - both in Arizona Oregon Health and Sciences University, K.A.K.) University of Denver, Denver (A.D.E.) Inova Fairfax Hospital, VA (K.K.E.) and Emory University
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link