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Paper Details

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Sci Transl Med
89
2016
Ala316Thr, GLP1R, Human, T2D, coronary heart disease, genes, glucagon-like peptide-1 receptor, glucose, heart disease, minor allele, obesity, rs10305492, type 2 diabetes
Author NameAffiliation
Robert A ScottMedical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Audrey Y ChuBrigham and Women's Hospital
Praveen SurendranUniversity of Cambridge
Robin YoungUniversity of Cambridge
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Alena StančákováUniversity of Eastern Finland
Tibor V VargaLund University
Hanieh YaghootkarUniversity of Exeter Medical School, University of Exeter
Jian'an LuanMedical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Jing Hua ZhaoMedical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Sara M WillemsMedical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Erasmus University Medical Center
Jennifer WesselFairbanks School of Public Health, Indiana University School of Medicine
Shuai WangBoston University School of Public Health
Christopher GillsonMedical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Philippe AmouyelUniversity of Lille, INSERM, Centre Hospitalier Regional Universitaire de Lille, Institut Pasteur de Lille
Beverley BalkauINSERM
Inês BarrosoThe Wellcome Trust Sanger Institute, UK. University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
Joshua C BisCardiovascular Health Research Unit, University of Washington
Stefan BlankenbergUniversity Heart Center Hamburg
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan ann arbor
Heiner BoeingGerman Institute of Human Nutrition
Eric BoerwinkleSchool of Public Health, University of Texas Health Science Center at Houston, Baylor College of Medicine
Eric BoerwinkleSchool of Public Health, University of Texas Health Science Center at Houston, Baylor College of Medicine
Ingrid B BoreckiWashington University School of Medicine
Jette Bork-JensenThe Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Carlos CaldasCancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge
Laura Adrienne CupplesBoston University School of Public Health, and Blood Institute (NHLBI)
Janet A DunnWarwick Clinical Trials Unit, University of Warwick
Georg EhretMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University
Jean FerrièresINSERM, Centre Hospitalier Universitaire (CHU) de Toulouse
Nita G ForouhiMedical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Carlos A GonzálezCatalan Institute of Oncology (ICO)
Marit E JørgensenSteno Diabetes Center, Denmark. National Institute of Public Health, Southern Denmark University
Rudolf KaaksGerman Cancer Research Centre (DKFZ)
Frank KeeUK Clinical Research Collaboration (UKCRC) Centre of Excellence for Public Health, Queen's University Belfast
Nicola D KerrisonMedical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Timothy J KeyUniversity of Oxford
Zsofia Kote-JaraiThe Institute of Cancer Research
Kari KuulasmaaNational Institute for Health and Welfare
Johanna KuusistoUniversity of Eastern Finland, Finland. Kuopio University Hospital
Allan LinnebergResearch Centre for Prevention and Health, Rigshospitalet, University of Copenhagen
Chunyu LiuNHLBI/National Institutes of Health (NIH)
Chunyu LiuNHLBI/National Institutes of Health (NIH)
Karen L MohlkeUniversity of North Carolina
Andrew P MorrisUniversity of Liverpool, University of Oxford
Andrew P MorrisUniversity of Liverpool, University of Oxford
Martina M??ller-NurasyidInstitute of Genetic Epidemiology, German Research Center for Environmental Health, Ludwig Maximilians University Munich
Martina M??ller-NurasyidInstitute of Genetic Epidemiology, German Research Center for Environmental Health, Ludwig Maximilians University Munich
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Carmen NavarroCIBER Epidemiologia y Salud Publica (CIBERESP)
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