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Paper Details

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.
Nature Communications
118
2021
SpCas9, cancer, cultured cell lines, double, endogenous loci, exogenous donor DNA, fluorescent reporter cells, mice, mouse, mouse liver, nucleotide, pathogenic allele, pegRNA, prime editing guide RNA, split-intein, tumor
Author NameAffiliation
Erik J SontheimerRNA Therapeutics Institute, University of Massachusetts Medical School
Erik J SontheimerUniversity of Massachusetts Medical School
Erik J SontheimerLi Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School
Guangping GaoUniversity of Massachusetts Medical School
Terence R FlotteUniversity of Massachusetts Medical School
Terence R FlotteUniversity of Massachusetts Medical School
Scot A WolfeUniversity of Massachusetts Medical School
Scot A WolfeLi Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School
Wen XueRNA Therapeutics Institute, University of Massachusetts Medical School
Wen XueUniversity of Massachusetts Medical School
Wen XueLi Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School
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