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Paper Details

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Life Sci Alliance
4
2022
COVID-19, CRISPR, Calu-3 cells, Cas9, CoV, EXOSC2, EXOSC2 protein, Nsp8, RNA exosome, RNA polymerase, SARS, SARS-, SARS-CoV-2, SARS-CoV-2 viral infection, gene-specific eQTLs, human, risk loci, viral RNA polymerase
COVID-19, Chromatography, Liquid, Codon, Nonsense, DNA-Directed RNA Polymerases, Exosome Multienzyme Ribonuclease Complex, Genome-Wide Association Study, Humans, RNA, Viral, RNA-Binding Proteins, SARS-CoV-2, Tandem Mass Spectrometry, Viral Replicase Complex Proteins, Virus Replication
Author NameAffiliation
Tobias MollSheffield Institute for Translational Neuroscience, University of Sheffield
Valerie OdonMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford
Calum HarveySheffield Institute for Translational Neuroscience, University of Sheffield
Mark O CollinsUniversity of Sheffield
Andrew A PedenUniversity of Sheffield
John FranklinSheffield Institute for Translational Neuroscience, University of Sheffield
Emily GravesSheffield Institute for Translational Neuroscience, University of Sheffield
Jack Ng MarshallSheffield Institute for Translational Neuroscience, University of Sheffield
Cleide Dos Santos SouzaSheffield Institute for Translational Neuroscience, University of Sheffield
Sai ZhangStanford University School of Medicine
Sai ZhangCenter for Genomics and Personalized Medicine, Stanford University School of Medicine
Lydia M CastelliSheffield Institute for Translational Neuroscience, University of Sheffield
Guillaume M HautbergueSheffield Institute for Translational Neuroscience, University of Sheffield
Mimoun AzzouzSheffield Institute for Translational Neuroscience, University of Sheffield
David E GordonUniversity of California San Francisco
David E GordonQuantitative Biosciences Institute, University of California San Francisco
Nevan J Krogan (CM4AI)University of California San Francisco
Nevan J Krogan (CM4AI)Quantitative Biosciences Institute, University of California San Francisco
Nevan J Krogan (CM4AI)Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes
Nevan J Krogan (CM4AI)Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG)
Laura FerraiuoloSheffield Institute for Translational Neuroscience, University of Sheffield
Michael P SnyderStanford University School of Medicine
Michael P SnyderCenter for Genomics and Personalized Medicine, Stanford University School of Medicine
Michael P SnyderStanford University School of Medicine
Michael P SnyderCenter for Genomics and Personalized Medicine, Stanford University School of Medicine
Pamela J ShawSheffield Institute for Translational Neuroscience, University of Sheffield
Jan RehwinkelMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford
Jonathan D CooperSheffield Institute for Translational Neuroscience, University of Sheffield
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