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Paper Details

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.
Cancer Discov
33
2021
-, AKT, AURKB, Aurora Kinase B, Aurora kinase B, BRAF, Degrader-resistant lines, KRAS, MS21, PI3K, PI3K/PTEN Pathway-Mutant Cancers, PTEN, RAS, T73E, cancer, cancer cell lines, hyperploidy, mice, mutant PI3K, pAKT, patients, threonine, tumor
Author NameAffiliation
Tiphaine C MartinIcahn School of Medicine at Mount Sinai
Tiphaine C MartinThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Ling XieUniversity of North Carolina at Chapel Hill
Shen YaoIcahn School of Medicine at Mount Sinai
Shen YaoThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Xian ChenUniversity of North Carolina at Chapel Hill
Jian JinIcahn School of Medicine at Mount Sinai
Jian JinThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Jian JinDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Jian JinMount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai
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