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Paper Details

Simvastatin in Critically Ill Patients with Covid-19.
N Engl J Med
5
2023
Author NameAffiliation
Carolyn S CalfeeFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
John C MarshallFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Anna McGlothlinFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Srinivas MurthyFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Kathryn M RowanFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Christopher W SeymourFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Manu Shankar-HariFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Pratik SinhaFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Boyd Taylor ThompsonFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Alexis F TurgeonFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
Derek C AngusFrom the Medical Research Institute of New Zealand, and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., University of Auckland (R.L.P.), S.M.B.) Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, Queen's University Belfast, Imperial College London (F.A.-B., the Intensive Care National Audit and Research Centre (C.A., University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., University of Edinburgh, University of Bristol, University Hospitals Bristol and Weston NHS Trust, Oxford (L.J.E.) - all in the United Kingdom Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, Raymond Poincare Hospital, Assistance Publique-Hopitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Federation Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane) King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Saudi Arabia (Y.A.) Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal) Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), Universite de Sherbrooke, McGill University Health Centre, University of British Columbia, the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, Universite Laval, and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada Julius Center for Health Sciences and Primary Care (M. Bonten, University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), and Radboud University Medical Center, S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoll Institute (S.W.) - both in Jena, Germany the School of Public Health and Preventive Medicine (A. Burrell, S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, University of Queensland, Princess Alexandra Hospital, University of California, and Harbor-university of california los angeles Medical Center, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.) National University Hospital Singapore, Singapore (M.E.C.) Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India the University of Antwerp, Sri Lanka (R.H.) Ziauddin University, Pakistan (M.H.) the University of Pittsburgh (D.T.H., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh Jikei University School of Medicine and the University of Tokyo, and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.) Universidad de La Sabana and Clinica Universidad de La Sabana - both in Chia, Colombia (L.F.R.) the Division of Clinical and Translational Research, Washington University School of Medicine, Massachusetts General Hospital, Harvard Medical School
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link