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Paper Details

BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors.
J Immunother Cancer
4
2023
AZD5153, BRD4, BRD4i, CD4, CD8, Cancer, FOXP3, ICB, MLH1, MMR genes, MMR-proficient tumors, MSH2, MSH6, Mismatch repair deficiency, PMS2, RNA, TIM-3, antitumor, bromodomain, bromodomain containing 4, cancers, cell lines, dMMR, genes, guanine, hypoxanthine, hypoxanthine-guanine phosphoribosyl transferase gene, ovarian cancer, pMMR, pMMR tumors, programmed death ligand, tumor, tumors
Author NameAffiliation
Gordon B MillsOregon Health & Science University Knight Cancer Institute
Gordon B MillsOregon Health & Science University Knight Cancer Institute
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Release 1.2