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Paper Details

WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Nature
206
2019
Cas9, DNA repair defects, MSI, MSI cancer models, MSI cancers, MSI models, PARP-1, RNA, RecQ DNA helicase, Synthetic lethality, WRN, WRN helicase, cancer, cancers, double-stranded DNA, exonuclease, helicase, microsatellite unstable cancers, poly(ADP-ribose), poly(ADP-ribose) polymerase 1
Author NameAffiliation
Mahmoud GhandiBroad Institute of Harvard and MIT
Alan D D'AndreaDana-Farber Cancer Institute, Harvard Medical School
Alan D D'AndreaDana-Farber Cancer Institute, Harvard Medical School
David E RootBroad Institute of Harvard and MIT
David E RootBroad Institute of Harvard and MIT
Jesse S BoehmBroad Institute of Harvard and MIT
Jesse S BoehmBroad Institute of Harvard and MIT
Gad GetzBroad Institute of Harvard and MIT
Gad GetzMassachusetts General Hospital Cancer Center
Gad GetzBroad Institute of Harvard and MIT
Gad GetzMassachusetts General Hospital Cancer Center
Todd R GolubBroad Institute of Harvard and MIT
Todd R GolubHoward Hughes Medical Institute
Todd R GolubDana-Farber Cancer Institute, Harvard Medical School
Todd R GolubBroad Institute of Harvard and MIT
Todd R GolubDana-Farber Cancer Institute, Harvard Medical School
Todd R GolubHoward Hughes Medical Institute
Aviad TsherniakBroad Institute of Harvard and MIT
Aviad TsherniakBroad Institute of Harvard and MIT
Francisca VazquezBroad Institute of Harvard and MIT
Francisca VazquezDana-Farber Cancer Institute, Harvard Medical School
Adam J BassBroad Institute of Harvard and MIT
Adam J BassDana-Farber Cancer Institute, Harvard Medical School
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