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Paper Details

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
J Clin Invest
99
2018
Cas9, EED, EZH2, EZH2 promoter, EZH2-regulated genes, IGFBP3, MYC transcription factors, MYCN, MYCN-amplified neuroblastoma, MYCN-amplified neuroblastomas, PRC2, SUZ12, cancer, childhood cancer neuroblastoma, histone deacetylase, neuroblastoma, neuroblastomas, oncogene MYCN, patients, polycomb repressive complex 2, tumor, tumors
Author NameAffiliation
Gabriela AlexeDana-Farber Cancer Institute and Boston Children's Hospital
Gabriela AlexeBoston University
Gabriela AlexeHarvard Medical School
Gabriela AlexeBroad Institute
Gabriela AlexeDana-Farber Cancer Institute and Boston Children's Hospital
Gabriela AlexeBroad Institute
Gabriela AlexeHarvard Medical School
Gabriela AlexeBoston University
Jun QiDana-Farber Cancer Institute
Francisca VazquezBroad Institute
Barbara A WeirBroad Institute
Barbara A WeirBroad Institute
Glenn S CowleyBroad Institute
Aviad TsherniakBroad Institute
Aviad TsherniakBroad Institute
David E RootBroad Institute
David E RootBroad Institute
James E BradnerHarvard Medical School
James E BradnerNovartis Institutes for BioMedical Research
James E BradnerDana-Farber Cancer Institute
Todd R GolubDana-Farber Cancer Institute and Boston Children's Hospital
Todd R GolubHarvard Medical School
Todd R GolubBroad Institute
Todd R GolubDana-Farber Cancer Institute and Boston Children's Hospital
Todd R GolubBroad Institute
Todd R GolubHarvard Medical School
Charles W M RobertsDana-Farber Cancer Institute and Boston Children's Hospital
Charles W M RobertsComprehensive Cancer Center and Department of Oncology, St. Jude Children's Research Hospital
William C HahnBroad Institute
William C HahnDana-Farber Cancer Institute
William C HahnHarvard Medical School
William C HahnBroad Institute
William C HahnHarvard Medical School
William C HahnDana-Farber Cancer Institute
William A WeissHelen Diller Family Comprehensive Cancer Center
William A WeissBrain Tumor Research Center
William A WeissHelen Diller Family Comprehensive Cancer Center
William A WeissBrain Tumor Research Center
Kimberly StegmaierDana-Farber Cancer Institute and Boston Children's Hospital
Kimberly StegmaierBroad Institute
Kimberly StegmaierHarvard Medical School
Kimberly StegmaierDana-Farber Cancer Institute and Boston Children's Hospital
Kimberly StegmaierBroad Institute
Kimberly StegmaierHarvard Medical School
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