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Paper Details

Dabrafenib plus Trametinib in Pediatric Glioma with <i>BRAF</i> V600 Mutations.
N Engl J Med
33
2023
Dabrafenib, Pediatric Glioma, Trametinib, V600 Mutations, V600 mutations, V600E mutation, carboplatin, dabrafenib, low-grade glioma, patients, pediatric, pediatric low-grade glioma, trametinib, vincristine
Author NameAffiliation
Eric BouffetFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Maria Luisa Garr??From the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Maria Luisa Garr??From the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Felix SahmFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Felix SahmFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Uri TaboriFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Roger J PackerFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Roger J PackerFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Olaf WittFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Olaf WittFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
Darren HargraveFrom the Hospital for Sick Children, University of Toronto, U.T.) the Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, and the Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australian immunoGENomics Cancer Institute, and the University of Adelaide, Adelaide - all in Australia (J.R.H.) IRCCS Giannina Gaslini Institute, and IRCCS Bambino Gesu Children's Hospital, Catholic University of the Sacred Heart, Rome (F.L.) - both in Italy Osaka City General Hospital, Japan (J.H.) the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.P.-F.) Institut Curie, SIREDO Oncology Center, Paris Sciences et Lettres Research University, Paris (I.A.) the Princess Maxima Center for Pediatric Oncology, the Netherlands (J.L.) Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Moscow (L.P.) the Department of Neuropathology and Clinical Cooperation Unit Neuropathology (F.S.) and the Hopp Children's Cancer Center, and National Center for Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, O.W.) the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (K.J.C.) Children's National Hospital, D.C. (R.J.P.) Novartis Pharma, A.B.P.S.) Novartis Pharmaceuticals, NJ (M.R.) and the University College London Great Ormond Street Institute of Child Health
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ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link