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Paper Details

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.
N Engl J Med
127
2022
Author NameAffiliation
Fran??ois LamontagneUniversite de Sherbrooke, the Department of Pharmacy (B.B.), Centre de Recherche du CHU de Sherbrooke, Centre Integre Universitaire de Sante et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (F. Lamontagne, and Bishop's University (D.C.), and the Population Health Research Institute (E.P.B.-C.), McMaster University, Juravinski Hospital (T.M.), University of Toronto (S.M., Queen's University, the Department of Pharmacy, Ottawa Hospital (S.K.), Ottawa Hospital Research Institute (S.K., University of Ottawa (A.J.E.S.), the Massawippi Valley Foundation, Universite de Montreal (M.C.), the Centre Hospitalier de l'Universite de Montreal (M.C., McGill University Health Centre (J.S.), Universite Laval, and the Research Center (F. Lauzier, CHU de Quebec-Universite Laval, University of Alberta, Schulich School of Medicine and Dentistry, Western University, Island Health Authority, Auckland City Hospital (R. Parke, University of Auckland (R. Parke), the Medical Research Institute of New Zealand, Wellington Hospital, University of Otago, Apollo Hospitals, and George Institute for Global Health, Raymond-Poincare Hospital (Assistance Publique-Hopitaux de Paris [AP-HP]), and Federation Hospitalo-Universitaire SEPSIS, Institut National de la Sante et de la Recherche Medicale, University Paris-Saclay Campus UVSQ, Hopitaux Universitaires Henri-Mondor, and Institut Mondor de Recherche Biomedicale, Universite Paris Est Creteil, Creteil (A.M.-D.) - all in France the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Saudi Arabia (Y.M.A.) and the Australian and New Zealand Intensive Care Research Centre, Monash University
Djillali AnnaneUniversite de Sherbrooke, the Department of Pharmacy (B.B.), Centre de Recherche du CHU de Sherbrooke, Centre Integre Universitaire de Sante et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (F. Lamontagne, and Bishop's University (D.C.), and the Population Health Research Institute (E.P.B.-C.), McMaster University, Juravinski Hospital (T.M.), University of Toronto (S.M., Queen's University, the Department of Pharmacy, Ottawa Hospital (S.K.), Ottawa Hospital Research Institute (S.K., University of Ottawa (A.J.E.S.), the Massawippi Valley Foundation, Universite de Montreal (M.C.), the Centre Hospitalier de l'Universite de Montreal (M.C., McGill University Health Centre (J.S.), Universite Laval, and the Research Center (F. Lauzier, CHU de Quebec-Universite Laval, University of Alberta, Schulich School of Medicine and Dentistry, Western University, Island Health Authority, Auckland City Hospital (R. Parke, University of Auckland (R. Parke), the Medical Research Institute of New Zealand, Wellington Hospital, University of Otago, Apollo Hospitals, and George Institute for Global Health, Raymond-Poincare Hospital (Assistance Publique-Hopitaux de Paris [AP-HP]), and Federation Hospitalo-Universitaire SEPSIS, Institut National de la Sante et de la Recherche Medicale, University Paris-Saclay Campus UVSQ, Hopitaux Universitaires Henri-Mondor, and Institut Mondor de Recherche Biomedicale, Universite Paris Est Creteil, Creteil (A.M.-D.) - all in France the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Saudi Arabia (Y.M.A.) and the Australian and New Zealand Intensive Care Research Centre, Monash University
Yaseen M ArabiUniversite de Sherbrooke, the Department of Pharmacy (B.B.), Centre de Recherche du CHU de Sherbrooke, Centre Integre Universitaire de Sante et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (F. Lamontagne, and Bishop's University (D.C.), and the Population Health Research Institute (E.P.B.-C.), McMaster University, Juravinski Hospital (T.M.), University of Toronto (S.M., Queen's University, the Department of Pharmacy, Ottawa Hospital (S.K.), Ottawa Hospital Research Institute (S.K., University of Ottawa (A.J.E.S.), the Massawippi Valley Foundation, Universite de Montreal (M.C.), the Centre Hospitalier de l'Universite de Montreal (M.C., McGill University Health Centre (J.S.), Universite Laval, and the Research Center (F. Lauzier, CHU de Quebec-Universite Laval, University of Alberta, Schulich School of Medicine and Dentistry, Western University, Island Health Authority, Auckland City Hospital (R. Parke, University of Auckland (R. Parke), the Medical Research Institute of New Zealand, Wellington Hospital, University of Otago, Apollo Hospitals, and George Institute for Global Health, Raymond-Poincare Hospital (Assistance Publique-Hopitaux de Paris [AP-HP]), and Federation Hospitalo-Universitaire SEPSIS, Institut National de la Sante et de la Recherche Medicale, University Paris-Saclay Campus UVSQ, Hopitaux Universitaires Henri-Mondor, and Institut Mondor de Recherche Biomedicale, Universite Paris Est Creteil, Creteil (A.M.-D.) - all in France the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Saudi Arabia (Y.M.A.) and the Australian and New Zealand Intensive Care Research Centre, Monash University
David M MasloveUniversite de Sherbrooke, the Department of Pharmacy (B.B.), Centre de Recherche du CHU de Sherbrooke, Centre Integre Universitaire de Sante et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (F. Lamontagne, and Bishop's University (D.C.), and the Population Health Research Institute (E.P.B.-C.), McMaster University, Juravinski Hospital (T.M.), University of Toronto (S.M., Queen's University, the Department of Pharmacy, Ottawa Hospital (S.K.), Ottawa Hospital Research Institute (S.K., University of Ottawa (A.J.E.S.), the Massawippi Valley Foundation, Universite de Montreal (M.C.), the Centre Hospitalier de l'Universite de Montreal (M.C., McGill University Health Centre (J.S.), Universite Laval, and the Research Center (F. Lauzier, CHU de Quebec-Universite Laval, University of Alberta, Schulich School of Medicine and Dentistry, Western University, Island Health Authority, Auckland City Hospital (R. Parke, University of Auckland (R. Parke), the Medical Research Institute of New Zealand, Wellington Hospital, University of Otago, Apollo Hospitals, and George Institute for Global Health, Raymond-Poincare Hospital (Assistance Publique-Hopitaux de Paris [AP-HP]), and Federation Hospitalo-Universitaire SEPSIS, Institut National de la Sante et de la Recherche Medicale, University Paris-Saclay Campus UVSQ, Hopitaux Universitaires Henri-Mondor, and Institut Mondor de Recherche Biomedicale, Universite Paris Est Creteil, Creteil (A.M.-D.) - all in France the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Saudi Arabia (Y.M.A.) and the Australian and New Zealand Intensive Care Research Centre, Monash University
Sangeeta MehtaUniversite de Sherbrooke, the Department of Pharmacy (B.B.), Centre de Recherche du CHU de Sherbrooke, Centre Integre Universitaire de Sante et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (F. Lamontagne, and Bishop's University (D.C.), and the Population Health Research Institute (E.P.B.-C.), McMaster University, Juravinski Hospital (T.M.), University of Toronto (S.M., Queen's University, the Department of Pharmacy, Ottawa Hospital (S.K.), Ottawa Hospital Research Institute (S.K., University of Ottawa (A.J.E.S.), the Massawippi Valley Foundation, Universite de Montreal (M.C.), the Centre Hospitalier de l'Universite de Montreal (M.C., McGill University Health Centre (J.S.), Universite Laval, and the Research Center (F. Lauzier, CHU de Quebec-Universite Laval, University of Alberta, Schulich School of Medicine and Dentistry, Western University, Island Health Authority, Auckland City Hospital (R. Parke, University of Auckland (R. Parke), the Medical Research Institute of New Zealand, Wellington Hospital, University of Otago, Apollo Hospitals, and George Institute for Global Health, Raymond-Poincare Hospital (Assistance Publique-Hopitaux de Paris [AP-HP]), and Federation Hospitalo-Universitaire SEPSIS, Institut National de la Sante et de la Recherche Medicale, University Paris-Saclay Campus UVSQ, Hopitaux Universitaires Henri-Mondor, and Institut Mondor de Recherche Biomedicale, Universite Paris Est Creteil, Creteil (A.M.-D.) - all in France the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Saudi Arabia (Y.M.A.) and the Australian and New Zealand Intensive Care Research Centre, Monash University
Alexis F TurgeonUniversite de Sherbrooke, the Department of Pharmacy (B.B.), Centre de Recherche du CHU de Sherbrooke, Centre Integre Universitaire de Sante et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (F. Lamontagne, and Bishop's University (D.C.), and the Population Health Research Institute (E.P.B.-C.), McMaster University, Juravinski Hospital (T.M.), University of Toronto (S.M., Queen's University, the Department of Pharmacy, Ottawa Hospital (S.K.), Ottawa Hospital Research Institute (S.K., University of Ottawa (A.J.E.S.), the Massawippi Valley Foundation, Universite de Montreal (M.C.), the Centre Hospitalier de l'Universite de Montreal (M.C., McGill University Health Centre (J.S.), Universite Laval, and the Research Center (F. Lauzier, CHU de Quebec-Universite Laval, University of Alberta, Schulich School of Medicine and Dentistry, Western University, Island Health Authority, Auckland City Hospital (R. Parke, University of Auckland (R. Parke), the Medical Research Institute of New Zealand, Wellington Hospital, University of Otago, Apollo Hospitals, and George Institute for Global Health, Raymond-Poincare Hospital (Assistance Publique-Hopitaux de Paris [AP-HP]), and Federation Hospitalo-Universitaire SEPSIS, Institut National de la Sante et de la Recherche Medicale, University Paris-Saclay Campus UVSQ, Hopitaux Universitaires Henri-Mondor, and Institut Mondor de Recherche Biomedicale, Universite Paris Est Creteil, Creteil (A.M.-D.) - all in France the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Saudi Arabia (Y.M.A.) and the Australian and New Zealand Intensive Care Research Centre, Monash University
Neill K J AdhikariUniversite de Sherbrooke, the Department of Pharmacy (B.B.), Centre de Recherche du CHU de Sherbrooke, Centre Integre Universitaire de Sante et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke (F. Lamontagne, and Bishop's University (D.C.), and the Population Health Research Institute (E.P.B.-C.), McMaster University, Juravinski Hospital (T.M.), University of Toronto (S.M., Queen's University, the Department of Pharmacy, Ottawa Hospital (S.K.), Ottawa Hospital Research Institute (S.K., University of Ottawa (A.J.E.S.), the Massawippi Valley Foundation, Universite de Montreal (M.C.), the Centre Hospitalier de l'Universite de Montreal (M.C., McGill University Health Centre (J.S.), Universite Laval, and the Research Center (F. Lauzier, CHU de Quebec-Universite Laval, University of Alberta, Schulich School of Medicine and Dentistry, Western University, Island Health Authority, Auckland City Hospital (R. Parke, University of Auckland (R. Parke), the Medical Research Institute of New Zealand, Wellington Hospital, University of Otago, Apollo Hospitals, and George Institute for Global Health, Raymond-Poincare Hospital (Assistance Publique-Hopitaux de Paris [AP-HP]), and Federation Hospitalo-Universitaire SEPSIS, Institut National de la Sante et de la Recherche Medicale, University Paris-Saclay Campus UVSQ, Hopitaux Universitaires Henri-Mondor, and Institut Mondor de Recherche Biomedicale, Universite Paris Est Creteil, Creteil (A.M.-D.) - all in France the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Saudi Arabia (Y.M.A.) and the Australian and New Zealand Intensive Care Research Centre, Monash University
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link