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Paper Details

TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.
Nat Genet
128
2017
-, -ERG fusion, CORE, COREs, ERG, ERG locus, ERG transcription factor, FOXA1, HOXB13, NOTCH, T2E, T2E-positive prostate cancer cells, T2E-positive prostate tumors, T2E-specific, TMPRSS2, TMPRSS2 locus, chromatin, cis, cis-regulatory landscape, cis-regulatory landscapes, pre, primary prostate cancer, primary prostate tumors, prostate tumors, regulatory elements
Cell Line, Tumor, Cell Movement, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hepatocyte Nuclear Factor 3-alpha, Homeodomain Proteins, Humans, Male, Oncogene Proteins, Fusion, Prostatic Neoplasms, RNA Interference, Receptors, Notch, Regulatory Sequences, Nucleic Acid, Reverse Transcriptase Polymerase Chain Reaction, Serine Endopeptidases, Signal Transduction, Transcription Factors, Transcriptional Regulator ERG
Author NameAffiliation
Ken J KronPrincess Margaret Cancer Centre, University Health Network
Alex MurisonPrincess Margaret Cancer Centre, University Health Network
Stanley ZhouPrincess Margaret Cancer Centre, University Health Network
Stanley ZhouUniversity of Toronto
Vincent HuangOntario Institute for Cancer Research
Takafumi N YamaguchiOntario Institute for Cancer Research
Yu-Jia ShiahOntario Institute for Cancer Research
Michael FraserPrincess Margaret Cancer Centre, University Health Network
Theodorus H van der KwastToronto General Hospital, University Health Network
Paul C BoutrosUniversity of Toronto
Paul C BoutrosOntario Institute for Cancer Research
Paul C BoutrosUniversity of Toronto
Robert G BristowPrincess Margaret Cancer Centre, University Health Network
Robert G BristowUniversity of Toronto
Robert G BristowUniversity of Toronto
Mathieu LupienPrincess Margaret Cancer Centre, University Health Network
Mathieu LupienUniversity of Toronto
Mathieu LupienOntario Institute for Cancer Research
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