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Paper Details

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
Nat Genet
48
2021
3,284 genes, 815, BRAF, BRAF mutant cells, CRISPR paralog targeting library, DUSP4, DUSP6, MAPK, NRAS, NRAS and BRAF mutant cells, cancer, cancers, functionally redundant genes, paralog families, paralog pairs
Author NameAffiliation
Brenton R PaolellaBroad Institute of Harvard and MIT
David E RootBroad Institute of Harvard and MIT
David E RootBroad Institute of Harvard and MIT
Gad GetzBroad Institute of Harvard and MIT
Gad GetzCancer Center and Department of Pathology, Massachusetts General Hospital
Gad GetzHarvard Medical School
Gad GetzBroad Institute of Harvard and MIT
Gad GetzHarvard Medical School
Gad GetzCancer Center and Department of Pathology, Massachusetts General Hospital
Francisca VazquezBroad Institute of Harvard and MIT
John G DoenchBroad Institute of Harvard and MIT
William R SellersBroad Institute of Harvard and MIT
William R SellersDana-Farber Cancer Institute
William R SellersHarvard Medical School
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