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Paper Details

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
N Engl J Med
645
2021
ACTIV, Covid, Covid-, Critically Ill, Patients, Thrombosis, coronavirus disease, critically ill, inflammation, patients
Author NameAffiliation
Michelle N GongFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Alexis F TurgeonFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Roger J LewisFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Anthony C GordonFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Matthew D NealFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Yaseen M ArabiFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Abhijit DuggalFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Jorge EscobedoFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Timothy D GirardFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Christopher M HorvatFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Akram KhanFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Mike LaffanFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Fran??ois LamontagneFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Christine M LeeperFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Anna McGlothlinFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Pauline K ParkFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Christopher W SeymourFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
Sean van DiepenFrom the University of Toronto (E.C.G., University Health Network (E.C.G., Peter Munk Cardiac Centre at University Health Network (P.R.L., Ottawa Hospital Research Institute (M. Carrier, Institut du Savoir Montfort (M. Carrier, and the University of Ottawa (L.A.C., the University of Manitoba (A. Kumar, Universite Laval and Centre Hospitalier Universitaire de Quebec-Universite Laval Research Center, McGill University, St. Michael's Hospital Unity Health, McMaster University and the Thrombosis and Atherosclerosis Research Institute, ON (P.L.G.) Universite de Sherbrooke, St. Boniface Hospital, the University of British Columbia, and the University of Alberta, Edmonton (S.D.) - all in Canada University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, the London School of Hygiene and Tropical Medicine (B.-A.K.), Imperial College London (A.C.G., Imperial College Healthcare NHS Trust, St. Mary's Hospital (A.C.G.), University College London Hospital (R.H.), and Inte
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link