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Paper Details

Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development.
Dev Cell
7
2023
Ciona robusta, ETS, ETS binding sites, GOF enhancer, Transcriptional enhancers, enhancer variants, enhancers, extra beating hearts, heart enhancers, human, human GATA4 enhancer, human induced pluripotent stem cell (iPSC)-derived cardiomyocytes, low-affinity binding sites, suboptimal-affinity sites
Author NameAffiliation
Adam KlieUniversity of California
Kelly A FrazerUniversity of California, USA Institute for Genomic Medicine
Kelly A FrazerUniversity of California, USA Institute for Genomic Medicine
Emma K FarleyUniversity of California
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