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Paper Details

Modeling the B-cell receptor signaling on single cell level reveals a stable network circuit topology between nonmalignant B cells and chronic lymphocytic leukemia cells and between untreated cells and cells treated with kinase inhibitors.
Int J Cancer
1
2022
AKT, B, B-cell receptor, BCR, BCR components, BCR signaling components, BTK, CLL, CLL cells, ERK1/2, H O, IGHV, IGHV mutated CLL cells, IGHV unmutated CLL cells, Idelalisib, LYN, PI3K, PLC, SYK, ZAP70, anti-CD19, anti-IgM, chronic lymphocytic leukemia, chronic lymphocytic leukemia cells, dasatinib, entospletinib, human, ibrutinib, malignant, malignant and, malignant and nonmalignant cells, malignant cells, mutated IGHV, nonmalignant B cells, nonmalignant cells, primary human leukemic cells, single cells, unmutated IGHV, untreated cells
Author NameAffiliation
Peter LichterGerman Cancer Research Center (DKFZ)
Peter LichterGerman Cancer Research Center (DKFZ)
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Release 1.2