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Paper Details

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.
N Engl J Med
3214
2018
ALL, Adults, B, B-Cell Lymphoblastic Leukemia, B-cell, B-cell ALL, B-cell acute lymphoblastic leukemia, CAR, CD19, CD19+, Children, T-cell, Tisagenlecleucel, anti-CD19, cerebral edema, children, chimeric antigen receptor, cytokine release syndrome, patients, tisagenlecleucel, tocilizumab
Author NameAffiliation
Kara L DavisPerelman School of Medicine, and Abramson Cancer Center (C.H.J., University of Pennsylvania, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Oslo University Hospital, Hospital Sant Joan de Deu Barcelona, University of Utah, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Hospital for Sick Children, Hospital for Children and Adolescents, University Hospital Frankfurt, University of Minnesota, H.E.S.) Children's Mercy Hospital and Clinics, Emory University, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Graduate School of Medicine Kyoto University, Stanford University School of Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, Duke University Medical Center, NC (P.L.M.) Oregon Health and Science University, Portland (E.R.N.) C.S. Mott Children's Hospital, St. Anna Children's Hospital, Vienna (C.P.) University Hospital Robert Debre and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris the Royal Children's Hospital, Australia (F.M.) Clinica Pediatrica Universita degli Studi di Milano Bicocca, Italy (A. Balduzzi) and Novartis Pharmaceuticals (P.W., D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover
Kara L DavisPerelman School of Medicine, and Abramson Cancer Center (C.H.J., University of Pennsylvania, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Oslo University Hospital, Hospital Sant Joan de Deu Barcelona, University of Utah, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Hospital for Sick Children, Hospital for Children and Adolescents, University Hospital Frankfurt, University of Minnesota, H.E.S.) Children's Mercy Hospital and Clinics, Emory University, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Graduate School of Medicine Kyoto University, Stanford University School of Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, Duke University Medical Center, NC (P.L.M.) Oregon Health and Science University, Portland (E.R.N.) C.S. Mott Children's Hospital, St. Anna Children's Hospital, Vienna (C.P.) University Hospital Robert Debre and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris the Royal Children's Hospital, Australia (F.M.) Clinica Pediatrica Universita degli Studi di Milano Bicocca, Italy (A. Balduzzi) and Novartis Pharmaceuticals (P.W., D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover
Paul L MartinPerelman School of Medicine, and Abramson Cancer Center (C.H.J., University of Pennsylvania, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Oslo University Hospital, Hospital Sant Joan de Deu Barcelona, University of Utah, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Hospital for Sick Children, Hospital for Children and Adolescents, University Hospital Frankfurt, University of Minnesota, H.E.S.) Children's Mercy Hospital and Clinics, Emory University, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Graduate School of Medicine Kyoto University, Stanford University School of Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, Duke University Medical Center, NC (P.L.M.) Oregon Health and Science University, Portland (E.R.N.) C.S. Mott Children's Hospital, St. Anna Children's Hospital, Vienna (C.P.) University Hospital Robert Debre and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris the Royal Children's Hospital, Australia (F.M.) Clinica Pediatrica Universita degli Studi di Milano Bicocca, Italy (A. Balduzzi) and Novartis Pharmaceuticals (P.W., D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover
Eneida R NemecekPerelman School of Medicine, and Abramson Cancer Center (C.H.J., University of Pennsylvania, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Oslo University Hospital, Hospital Sant Joan de Deu Barcelona, University of Utah, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Hospital for Sick Children, Hospital for Children and Adolescents, University Hospital Frankfurt, University of Minnesota, H.E.S.) Children's Mercy Hospital and Clinics, Emory University, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Graduate School of Medicine Kyoto University, Stanford University School of Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, Duke University Medical Center, NC (P.L.M.) Oregon Health and Science University, Portland (E.R.N.) C.S. Mott Children's Hospital, St. Anna Children's Hospital, Vienna (C.P.) University Hospital Robert Debre and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris the Royal Children's Hospital, Australia (F.M.) Clinica Pediatrica Universita degli Studi di Milano Bicocca, Italy (A. Balduzzi) and Novartis Pharmaceuticals (P.W., D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover
Carl H JunePerelman School of Medicine, and Abramson Cancer Center (C.H.J., University of Pennsylvania, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Oslo University Hospital, Hospital Sant Joan de Deu Barcelona, University of Utah, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Hospital for Sick Children, Hospital for Children and Adolescents, University Hospital Frankfurt, University of Minnesota, H.E.S.) Children's Mercy Hospital and Clinics, Emory University, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Graduate School of Medicine Kyoto University, Stanford University School of Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, Duke University Medical Center, NC (P.L.M.) Oregon Health and Science University, Portland (E.R.N.) C.S. Mott Children's Hospital, St. Anna Children's Hospital, Vienna (C.P.) University Hospital Robert Debre and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris the Royal Children's Hospital, Australia (F.M.) Clinica Pediatrica Universita degli Studi di Milano Bicocca, Italy (A. Balduzzi) and Novartis Pharmaceuticals (P.W., D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover
Stephan A GruppPerelman School of Medicine, and Abramson Cancer Center (C.H.J., University of Pennsylvania, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia (S.L.M., S.A.G.) - all in Philadelphia the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Oslo University Hospital, Hospital Sant Joan de Deu Barcelona, University of Utah, University of Montreal, and the Hematology Oncology Division and Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Hospital for Sick Children, Hospital for Children and Adolescents, University Hospital Frankfurt, University of Minnesota, H.E.S.) Children's Mercy Hospital and Clinics, Emory University, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Graduate School of Medicine Kyoto University, Stanford University School of Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, Duke University Medical Center, NC (P.L.M.) Oregon Health and Science University, Portland (E.R.N.) C.S. Mott Children's Hospital, St. Anna Children's Hospital, Vienna (C.P.) University Hospital Robert Debre and University Paris Diderot (A. Baruchel), and Saint-Louis Hospital and University Paris Diderot (N.B.), Paris the Royal Children's Hospital, Australia (F.M.) Clinica Pediatrica Universita degli Studi di Milano Bicocca, Italy (A. Balduzzi) and Novartis Pharmaceuticals (P.W., D.L.) and Novartis Institutes for Biomedical Research (K.T.M.) - both in East Hanover
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ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
Release 1.2