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Paper Details

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.
PLoS Genet
27
2018
CHIP, CHIP U, CHIP U-box domain, CHIP mutations, SCAR16, T246M, carboxyl, carboxyl terminus of heat shock 70-interacting protein, cerebellar dysfunction, cognitive deficits, deficits in learning and memory, endogenous locus, genetic disease, mice, patients, rats, spinocerebellar autosomal recessive 16, ubiquitin ligase, ubiquitin ligase domain
Author NameAffiliation
Walter J ChazinCenter for Structural Biology, Vanderbilt University
Pan DuNational Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, Academy of Medical Sciences, at Zhengzhou University
Jonathan C SchislerMcAllister Heart Institute at The University of North Carolina at Chapel Hill
Jonathan C Schislerand Department of Pathology and Lab Medicine at The University of North Carolina at Chapel Hill
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