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Paper Details

A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.
Am J Hum Genet
6
2021
7p21, 8-tetrachlorodibenzo-p-dioxin, AHR, TCDD, UVB-responsive common variant, UVB-responsive element, allele, aryl hydrocarbon, aryl hydrocarbon receptor, binding to, cSCC, causal gene, chromatin state, chromosome band 7p21, cutaneous squamous cell carcinoma, dioxin, identified, luciferase, melanocyte, melanocyte cell, melanoma, melanoma-associated locus, primary melanocytes, promoter, protective, rs117132860, rs117132860-, rs117132860-G allele, rs73069846
Author NameAffiliation
Alessandra ChesiPerelman School of Medicine, University of Pennsylvania
Matthew E JohnsonCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Andrew D WellsCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Helen T MichaelCenter for Cancer Research, National Cancer Institute
Helen T MichaelCenter for Cancer Research, National Cancer Institute
Maria Teresa LandiNational Cancer Institute
Stephen J ChanockNational Cancer Institute
Stephen J ChanockNational Cancer Institute
Struan F A GrantCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, USA Perelman School of Medicine
Struan F A GrantCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, USA Perelman School of Medicine
Raj ChariNational Cancer Institute
Glenn MerlinoCenter for Cancer Research, National Cancer Institute
Glenn MerlinoCenter for Cancer Research, National Cancer Institute
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