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Paper Details

Discovery of a first-in-class EZH2 selective degrader.
Nat Chem Biol
125
2020
EZH2, H3K27me3, MS1943, PRC2 complex, TNBC, TNBC cells, cancer, cancers, enhancer of zeste, enhancer of zeste homolog 2, follicular lymphoma, histone H3, lysine, normal cells, sarcoma, triple-negative breast cancer
Author NameAffiliation
Tiphaine C MartinTisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Alexander RialdiTisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Ernesto GuccioneMount Sinai Center for Therapeutics Discovery, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Ernesto GuccioneTisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Jian JinMount Sinai Center for Therapeutics Discovery, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Jian JinTisch Cancer Institute, Icahn School of Medicine at Mount Sinai
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Release 1.2