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Paper Details

A genomic mutational constraint map using variation in 76,156 human genomes.
Nature
64
2024
allele frequency reference dataset, constrained genes, constrained regions, genome, human, human genome, human genomes, non-coding DNA, non-coding genome, non-coding regions, non-protein-coding regions, protein-coding genes, protein-coding sequences, regulatory elements
Author NameAffiliation
Masahiro KanaiBroad Institute of MIT and Harvard
Masahiro KanaiMassachusetts General Hospital
Jessica AlföldiBroad Institute of MIT and Harvard
Jessica AlföldiMassachusetts General Hospital
Nicholas A WattsBroad Institute of MIT and Harvard
Nicholas A WattsMassachusetts General Hospital
Laura GauthierBroad Institute of MIT and Harvard
Yossi FarjounLady Davis Institute
Eric BanksBroad Institute of MIT and Harvard
Eric BanksBroad Institute of MIT and Harvard
Stacey DonnellyBroad Institute of MIT and Harvard
Anne O'Donnell-LuriaBroad Institute of MIT and Harvard
Anne O'Donnell-LuriaBoston Children's Hospital
Anne O'Donnell-LuriaCenter for Genomic Medicine, Massachusetts General Hospital
Anne O'Donnell-LuriaBroad Institute of MIT and Harvard
Anne O'Donnell-LuriaCenter for Genomic Medicine, Massachusetts General Hospital
Anne O'Donnell-LuriaBoston Children's Hospital
Alicia R MartinBroad Institute of MIT and Harvard
Alicia R MartinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
Alicia R MartinMassachusetts General Hospital
Mark J DalyBroad Institute of MIT and Harvard
Mark J DalyInstitute for Molecular Medicine Finland (FIMM)
Mark J DalyMassachusetts General Hospital
Mark J DalyBroad Institute of MIT and Harvard
Mark J DalyMassachusetts General Hospital
Mark J DalyInstitute for Molecular Medicine Finland (FIMM)
Grace TiaoBroad Institute of MIT and Harvard
Grace TiaoMassachusetts General Hospital
Daniel G MacArthurBroad Institute of MIT and Harvard
Daniel G MacArthurMurdoch Children's Research Institute
Daniel G MacArthurGarvan Institute of Medical Research and UNSW Sydney
Daniel G MacArthurBroad Institute of MIT and Harvard
Daniel G MacArthurGarvan Institute of Medical Research and UNSW Sydney
Daniel G MacArthurMurdoch Children's Research Institute
Konrad J KarczewskiBroad Institute of MIT and Harvard
Konrad J KarczewskiMassachusetts General Hospital
Konrad J KarczewskiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
Konrad J KarczewskiBroad Institute of MIT and Harvard
Konrad J KarczewskiMassachusetts General Hospital
Konrad J KarczewskiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
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