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Paper Details

Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Metabolism
5
2023
Fructose, KHK, KHK) C isoform, KHK-C, NAFLD, Non-alcoholic fatty liver disease, cultured hepatocytes, fructose, hepatic KHK, hepatic transcriptome, human, insulin, ketohexokinase, ketohexokinase (, liver disease, liver injury, metabolic complications, metabolic dysfunction, metabolic syndrome, mice, obesity, sugar, triglycerides
Author NameAffiliation
Leila NoetzliAlnylam Pharmaceuticals Inc.
Jonathan M DreyfussJoslin Diabetes Center, Harvard Medical School
Birgit SchillingBuck Institute for Research on Aging
Birgit SchillingBuck Institute for Research on Aging
Aldons J LusisA2- Center for the Health Sciences, University of California los angeles
Kevin FitzgeraldAlnylam Pharmaceuticals Inc.
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Release 1.2