CONCLUSIONS, Colitis, DSS colitis, Epithelial-macrophage, Human, Human Caco-2BBe intestinal epithelial cells, IBD, IEC, IECs, IL-22, IL-6, Intestinal Barrier Defects, JAK, Janus-kinase, LysMCre, PTPN2, PTPN2-specific shRNA, Ptpn2, Ptpn2fl, STAT, STAT3, THP-1 macrophages, Tofacitinib, colonic, epithelial-, fluorescein, inflammatory bowel diseases, intestinal epithelial, intestinal epithelial cell, macrophage, macrophages, mice, myeloid cells, patients, pro-inflammatory macrophages, protein tyrosine phosphatase non-receptor type-2, signal transducer and activator of transcription, sodium, sulphate, tofacitinib, tofacitinib citrate, tyrosine, ulcerative colitis