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Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of <i>FAIM2</i>.
bioRxiv
0
2023
3' UTR, Cas9, ch12q13, ch12q13 locus, ch12q13 obesity locus, childhood obesity, childhood obesity chr12q13 locus, childhood obesity loci, chromatin, down-, effector genes, genomic region, human, human primary astrocytes, hypothalamic neurons, immediate region, isogenic human embryonic stem cell lines, luciferase, luciferase reporter, neuron differentiation gene sets, neurons, non-coding region, obesity, rs7132908, rs7132908 allele
Author NameAffiliation
Alessandra ChesiCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Alessandra ChesiPerelman School of Medicine, University of Pennsylvania
James A PippinCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Stewart A AndersonChildren's Hospital of Philadelphia
Stewart A AndersonPerelman School of Medicine, University of Pennsylvania
Matthew C PahlCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Struan F A GrantCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Struan F A GrantPerelman School of Medicine, University of Pennsylvania
Struan F A GrantPerelman School of Medicine, University of Pennsylvania
Struan F A GrantChildren's Hospital of Philadelphia
Struan F A GrantChildren's Hospital of Philadelphia
Struan F A GrantCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Struan F A GrantPerelman School of Medicine, University of Pennsylvania
Struan F A GrantPerelman School of Medicine, University of Pennsylvania
Struan F A GrantChildren's Hospital of Philadelphia
Struan F A GrantChildren's Hospital of Philadelphia
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