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Paper Details

Polypill Strategy in Secondary Cardiovascular Prevention.
N Engl J Med
95
2022
ACE, angiotensin-converting-enzyme, aspirin, atorvastatin, cardiovascular death, ischemic stroke, myocardial infarction, nonfatal, nonfatal ischemic stroke, nonfatal type 1 myocardial infarction, patients, ramipril, statin
Author NameAffiliation
Jos?? M CastellanoHospital Universitario Monteprincipe, Grupo HM Hospitales (J.M.C.), Hospital Clinico San Carlos, Universidad Complutense (A.F.-O., Unidad de Investigacion Clinica y Ensayos Clinicos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (A.D.-F.), Health Research Institute, October 12 Hospital (H.B.), Fundacion Jimenez Diaz University Hospital (J.F.F., and Universidad Autonoma de Madrid (J.F.F.), Hospital Universitario Salamanca, Hospital Clinico Universitario Virgen de la Arrixaca, Hospital Universitario A Coruna, Instituto de Investigacion Biomedica A Coruna, Hospital Universitario de Cabuenes, University Clinical Hospital of Santiago de Compostela, Hospital Universitario Rey Juan Carlos, Hospital General Universitario de Alicante (N.L.), Hospital Universitario de San Juan (A.C.), London School of Hygiene and Tropical Medicine, and Imperial College NHS Trust (A.A.G.), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool (M.P.) - all in the United Kingdom Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School (D.L.B.) - both in Boston the Laboratory of Cardiovascular Prevention (M.C.R., Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, IRCCS Istituti Clinici Scientifici Maugeri (M.P.), University of Milan (M.P.), and the Clinical and Rehabilitation Cardiology Unit, San Filippo Neri Hospital, S.A.D.F.) - all in Italy Berlin Institute of Health-Center for Regenerative Therapies, German Center for Cardiovascular Research, and the Center for Stroke Research Berlin, Charite Universitatsmedizin - all in Berlin (W.D., University Hospital Besancon (F.S., and University of Burgundy Franche-Comte (F.S., Assistance Publique-Hopitaux de Paris, Sorbonne Universite, University Hospital of Dijon Burgundy (Y.B.), the Medical School of Dijon, University of Burgundy (Y.B.), Charles University, and General University Hospital - both in Prague (A.L., Medical University, University of Leuven, Zealand University Hospital, Denmark (M.M.S.) and the Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
Deepak L BhattHospital Universitario Monteprincipe, Grupo HM Hospitales (J.M.C.), Hospital Clinico San Carlos, Universidad Complutense (A.F.-O., Unidad de Investigacion Clinica y Ensayos Clinicos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (A.D.-F.), Health Research Institute, October 12 Hospital (H.B.), Fundacion Jimenez Diaz University Hospital (J.F.F., and Universidad Autonoma de Madrid (J.F.F.), Hospital Universitario Salamanca, Hospital Clinico Universitario Virgen de la Arrixaca, Hospital Universitario A Coruna, Instituto de Investigacion Biomedica A Coruna, Hospital Universitario de Cabuenes, University Clinical Hospital of Santiago de Compostela, Hospital Universitario Rey Juan Carlos, Hospital General Universitario de Alicante (N.L.), Hospital Universitario de San Juan (A.C.), London School of Hygiene and Tropical Medicine, and Imperial College NHS Trust (A.A.G.), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool (M.P.) - all in the United Kingdom Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School (D.L.B.) - both in Boston the Laboratory of Cardiovascular Prevention (M.C.R., Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, IRCCS Istituti Clinici Scientifici Maugeri (M.P.), University of Milan (M.P.), and the Clinical and Rehabilitation Cardiology Unit, San Filippo Neri Hospital, S.A.D.F.) - all in Italy Berlin Institute of Health-Center for Regenerative Therapies, German Center for Cardiovascular Research, and the Center for Stroke Research Berlin, Charite Universitatsmedizin - all in Berlin (W.D., University Hospital Besancon (F.S., and University of Burgundy Franche-Comte (F.S., Assistance Publique-Hopitaux de Paris, Sorbonne Universite, University Hospital of Dijon Burgundy (Y.B.), the Medical School of Dijon, University of Burgundy (Y.B.), Charles University, and General University Hospital - both in Prague (A.L., Medical University, University of Leuven, Zealand University Hospital, Denmark (M.M.S.) and the Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
Frans Van de WerfHospital Universitario Monteprincipe, Grupo HM Hospitales (J.M.C.), Hospital Clinico San Carlos, Universidad Complutense (A.F.-O., Unidad de Investigacion Clinica y Ensayos Clinicos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (A.D.-F.), Health Research Institute, October 12 Hospital (H.B.), Fundacion Jimenez Diaz University Hospital (J.F.F., and Universidad Autonoma de Madrid (J.F.F.), Hospital Universitario Salamanca, Hospital Clinico Universitario Virgen de la Arrixaca, Hospital Universitario A Coruna, Instituto de Investigacion Biomedica A Coruna, Hospital Universitario de Cabuenes, University Clinical Hospital of Santiago de Compostela, Hospital Universitario Rey Juan Carlos, Hospital General Universitario de Alicante (N.L.), Hospital Universitario de San Juan (A.C.), London School of Hygiene and Tropical Medicine, and Imperial College NHS Trust (A.A.G.), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool (M.P.) - all in the United Kingdom Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School (D.L.B.) - both in Boston the Laboratory of Cardiovascular Prevention (M.C.R., Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, IRCCS Istituti Clinici Scientifici Maugeri (M.P.), University of Milan (M.P.), and the Clinical and Rehabilitation Cardiology Unit, San Filippo Neri Hospital, S.A.D.F.) - all in Italy Berlin Institute of Health-Center for Regenerative Therapies, German Center for Cardiovascular Research, and the Center for Stroke Research Berlin, Charite Universitatsmedizin - all in Berlin (W.D., University Hospital Besancon (F.S., and University of Burgundy Franche-Comte (F.S., Assistance Publique-Hopitaux de Paris, Sorbonne Universite, University Hospital of Dijon Burgundy (Y.B.), the Medical School of Dijon, University of Burgundy (Y.B.), Charles University, and General University Hospital - both in Prague (A.L., Medical University, University of Leuven, Zealand University Hospital, Denmark (M.M.S.) and the Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
Valentin FusterHospital Universitario Monteprincipe, Grupo HM Hospitales (J.M.C.), Hospital Clinico San Carlos, Universidad Complutense (A.F.-O., Unidad de Investigacion Clinica y Ensayos Clinicos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (A.D.-F.), Health Research Institute, October 12 Hospital (H.B.), Fundacion Jimenez Diaz University Hospital (J.F.F., and Universidad Autonoma de Madrid (J.F.F.), Hospital Universitario Salamanca, Hospital Clinico Universitario Virgen de la Arrixaca, Hospital Universitario A Coruna, Instituto de Investigacion Biomedica A Coruna, Hospital Universitario de Cabuenes, University Clinical Hospital of Santiago de Compostela, Hospital Universitario Rey Juan Carlos, Hospital General Universitario de Alicante (N.L.), Hospital Universitario de San Juan (A.C.), London School of Hygiene and Tropical Medicine, and Imperial College NHS Trust (A.A.G.), University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool (M.P.) - all in the United Kingdom Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School (D.L.B.) - both in Boston the Laboratory of Cardiovascular Prevention (M.C.R., Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, IRCCS Istituti Clinici Scientifici Maugeri (M.P.), University of Milan (M.P.), and the Clinical and Rehabilitation Cardiology Unit, San Filippo Neri Hospital, S.A.D.F.) - all in Italy Berlin Institute of Health-Center for Regenerative Therapies, German Center for Cardiovascular Research, and the Center for Stroke Research Berlin, Charite Universitatsmedizin - all in Berlin (W.D., University Hospital Besancon (F.S., and University of Burgundy Franche-Comte (F.S., Assistance Publique-Hopitaux de Paris, Sorbonne Universite, University Hospital of Dijon Burgundy (Y.B.), the Medical School of Dijon, University of Burgundy (Y.B.), Charles University, and General University Hospital - both in Prague (A.L., Medical University, University of Leuven, Zealand University Hospital, Denmark (M.M.S.) and the Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
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ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
Release 1.2