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Paper Details

RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function.
J Biol Chem
88
2002
-derived mast cells, 18 exons, 2, >15-kb hRasGRP4 gene, H-Ras, HMC-1 cell line, HMC-1 leukemia cells, Human, Human Genome, Human and mouse MCs, MC, MC leukemia, MCs, RasGRP family, RasGRP4, RasGRP4 gene, Recombinant RasGRP4, amino acid, asthma, bone marrow, cDNA, calcium, chromosome 19q13, diacylglycerol, diacylglycerol/phorbol ester receptor, guanine nucleotide, hRasGRP4, homolog, human, human gene, interleukin 3, intron 5, mRNA, mRasGRP4, mast cell, mast cell leukemia, mast cell-restricted Ras guanine nucleotide-releasing protein, mastocytosis, mononuclear progenitors, mouse, mouse and human genomes, mouse bone marrow-derived mast cells, patient, patients, phorbol ester, precursor transcript, single nucleotide polymorphisms
Amino Acid Sequence, Animals, Asthma, Base Sequence, Calcium, Cloning, Molecular, DNA, Complementary, Diglycerides, Guanine Nucleotide Exchange Factors, Humans, Leukemia, Mast-Cell, Mast Cells, Mastocytosis, Models, Molecular, Molecular Sequence Data, Protein Conformation, Sequence Homology, Amino Acid, Signal Transduction, ras Guanine Nucleotide Exchange Factors
Author NameAffiliation
Yi YangBrigham and Women's Hospital, Harvard Medical School
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Release 1.2