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Paper Details

Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i>-Driven Uveal Melanoma.
Clin Cancer Res
33
2021
Cas9, ERK, FAK, GNA11, GNAQ, Gq, Gq proteins, MEK, PKC, PLC, Uveal Melanoma, Uveal melanoma, YAP1, cancer, eye cancer, focal adhesion kinase, mUM, metastatic uveal melanoma, patients, sgRNA, sgRNAs, tumor, uveal melanoma, uveal melanoma cells
Animals, Combined Modality Therapy, Female, Focal Adhesion Kinase 1, GTP-Binding Protein alpha Subunits, Gq-G11, Gain of Function Mutation, Genetic Testing, HEK293 Cells, Humans, MAP Kinase Signaling System, Melanoma, Mice, Inbred NOD, Mice, SCID, Molecular Targeted Therapy, Uveal Neoplasms, Xenograft Model Antitumor Assays
Author NameAffiliation
Justine S ParadisMoores Cancer Center, University of California San Diego
Monica AcostaMoores Cancer Center, University of California San Diego
Robert Saddawi-KonefkaMoores Cancer Center, University of California San Diego
Robert Saddawi-KonefkaUniversity of California San Diego
Ayush KishoreMoores Cancer Center, University of California San Diego
Frederico GomesMoores Cancer Center, University of California San Diego
Nadia ArangMoores Cancer Center, University of California San Diego
Nadia ArangUniversity of California San Diego
Manoela TiagoThomas Jefferson University
Silvia Coma
Simone LubranoMoores Cancer Center, University of California San Diego
Xingyu WuMoores Cancer Center, University of California San Diego
Kyle FordUniversity of California San Diego
Chi-Ping DayCenter for Cancer Research
Chi-Ping DayCenter for Cancer Research
Glenn MerlinoCenter for Cancer Research
Glenn MerlinoCenter for Cancer Research
Prashant Mali (CM4AI)University of California San Diego
Jonathan A Pachter
Takami SatoThomas Jefferson University
Takami SatoSidney Kimmel Cancer Center, Thomas Jefferson University
Andrew E AplinThomas Jefferson University
Andrew E AplinSidney Kimmel Cancer Center, Thomas Jefferson University
Jorge Silvio GutkindMoores Cancer Center, University of California San Diego
Jorge Silvio GutkindUniversity of California San Diego
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