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Paper Details

Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.
Nature Neuroscience
19
2022
FAN1, FAN1 nuclease, HD, HTT CAG repeat, HTT CAG repeat length, Huntington's disease, candidate modifier genes, induced pluripotent stem cell model, patients
Author NameAffiliation
Marcy E MacDonaldCenter for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School
Marcy E MacDonaldBroad Institute
James F GusellaCenter for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School
James F GusellaBroad Institute
Peter HolmansDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University
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