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Paper Details

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.
Science
128
2021
COVID-19, Phospholipidosis, SARS-, SARS-CoV, SARS-CoV-2, amiodarone, azithromycin, hydroxychloroquine, phospholipidosis, severe acute respiratory syndrome coronavirus, sigma receptor
A549 Cells, Animals, Antiviral Agents, COVID-19, COVID-19 Drug Treatment, Cations, Chlorocebus aethiops, Dose-Response Relationship, Drug, Drug Repositioning, Female, Humans, Lipidoses, Mice, Microbial Sensitivity Tests, Phospholipids, SARS-CoV-2, Surface-Active Agents, Vero Cells, Virus Replication
Author NameAffiliation
Tia A TumminoDepartment of Pharmaceutical Chemistry, University of California San Francisco (UCSF)
Tia A Tummino
Tia A TumminoQuantitative Biosciences Institute (QBI)
Tia A TumminoGraduate Program in Pharmaceutical Sciences and Pharmacogenomics
Veronica V RezeljInstitut Pasteur, CNRS UMR 3569
Benoit FischerNovartis Institutes for BioMedical Research, Preclinical Safety
Audrey FischerNovartis Institutes for BioMedical Research, Preclinical Safety
Matthew J O'MearaUniversity of Michigan ann arbor
Blandine MonelInstitut Pasteur, CNRS UMR 3569
Thomas ValletInstitut Pasteur, CNRS UMR 3569
Kris M WhiteIcahn School of Medicine at Mount Sinai
Kris M WhiteGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
Ziyang ZhangQuantitative Biosciences Institute (QBI)
Ziyang ZhangHoward Hughes Medical Institute
Ziyang Zhang
Ziyang Zhang
Assaf AlonBlavatnik Institute, Harvard Medical School
Heiko S SchadtNovartis Institutes for BioMedical Research, Preclinical Safety
Henry R O'DonnellDepartment of Pharmaceutical Chemistry, University of California San Francisco (UCSF)
Jiankun LyuDepartment of Pharmaceutical Chemistry, University of California San Francisco (UCSF)
Jiankun Lyu
Jiankun LyuQuantitative Biosciences Institute (QBI)
Romel RosalesIcahn School of Medicine at Mount Sinai
Romel RosalesGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
Briana L McGovernIcahn School of Medicine at Mount Sinai
Briana L McGovernGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
Raveen RathnasingheIcahn School of Medicine at Mount Sinai
Raveen RathnasingheGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
Raveen RathnasingheIcahn School of Medicine at Mount Sinai
Sonia JangraIcahn School of Medicine at Mount Sinai
Sonia JangraGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
Michael SchotsaertIcahn School of Medicine at Mount Sinai
Michael SchotsaertGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
Jean-Rene GalarneauNovartis Institutes for BioMedical Research, Preclinical Safety
Nevan J Krogan (CM4AI)Quantitative Biosciences Institute (QBI)
Nevan J Krogan (CM4AI)
Nevan J Krogan (CM4AI)
Nevan J Krogan (CM4AI)Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes
Laszlo UrbanNovartis Institutes for BioMedical Research, Preclinical Safety
Kevan M ShokatQuantitative Biosciences Institute (QBI)
Kevan M Shokat
Kevan M Shokat
Kevan M ShokatHoward Hughes Medical Institute
Andrew C KruseBlavatnik Institute, Harvard Medical School
Adolfo Garc??a-SastreIcahn School of Medicine at Mount Sinai
Adolfo Garc??a-SastreGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
Adolfo Garc??a-SastreIcahn School of Medicine at Mount Sinai
Adolfo Garc??a-SastreTisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Olivier SchwartzInstitut Pasteur, CNRS UMR 3569
Marco VignuzziInstitut Pasteur, CNRS UMR 3569, France. francois.pognan@novartis.com marco.vignuzzi@pasteur.fr francesca.moretti@novartis.com.
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