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Paper Details

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.
Genetics
31
2020
ADEP4, B. subtilis, Bacillus subtilis, CLPP, ClpP, ClpP Protease, E. coli, Enterococcus faecium, Escherichia coli, Gram, Gram-negative species, Imipridone, MIPEP, Neisseria gonorrhoeae, ONC201, ONC212, S. aureus, Staphylococcus aureus, acyldepsipeptide-4, antibiotic, bacterial ClpP, cancer, genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) knockout library, human, human cells, humans, imipridone, imipridones, impridones, mitochondrial intermediate peptidase MIPEP, mitochondrial matrix protease, rifampin, tolerant S.
Author NameAffiliation
Almer M van der SlootInstitute for Research in Immunology and Cancer, University of Montreal
Jasmin Coulombe-HuntingtonInstitute for Research in Immunology and Cancer, University of Montreal
Mike TyersInstitute for Research in Immunology and Cancer, University of Montreal
Mike TyersInstitute for Research in Immunology and Cancer, University of Montreal
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