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Paper Details

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification.
RSC Chem Biol
1
2023
3'-phosphodiester, DNA, H263, His-Lys-Asn, TDP1, TDP1 catalytic domain, TOP1, TOP1 peptide, TOP1 peptide-binding grooves, TOP1-DNA substrate-binding region, Tyrosyl-DNA phosphodiesterase 1, Y723, aldehydes, aminooxy, ether, hydrogen, imidazopyridine, oxime, oximes, phospholipase D family, substrate DNA, triazole, type I topoisomerase, tyrosyl-DNA phosphodiesterase 1
Author NameAffiliation
Yves PommierCenter for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA.
Yves PommierCenter for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA.
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Release 1.2