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Paper Details

NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.
Hepatology
8
2021
-, ABCB11, ABCC2, ABCG5, ABCG5/8, ATP, ATP binding cassette subfamily B member 11, ATP binding cassette subfamily C, ATP binding cassette subfamily C member 2, ATP binding cassette subfamily G member 5/8, Abcg5/8, BSEP, C57BL, Cyp7a1 promoter, DLPC, DSS, FXR, GSK2033, HepG2 cells, IL-, IL-1, IL-1-exposed HepG2 cells, Il-1r, Il-1r-/- /, Interleukin-1 receptor, LRH-1, LRH-1 promoter, LRH-1 protein, LXR, ML179, MRP2, NF-B, NR0B2, PN, PN-associated cholestasis, PNAC, Parenteral Nutrition-Associated Cholestasis, Phytosterol, SHP, SHP promoter, bile salt, bile salt export pump, dilauroyl phosphatidylcholine, downstream genes, exposed HepG2 cells, farnesoid, farnesoid X receptor, genes, hepatic mRNA, hepatic nuclear receptor subfamily 5, intestinal failure, liver X receptor, mRNA, mice, mouse, multidrug resistance associated protein 2, murine, nuclear receptor liver receptor homolog 1, nuclear receptor subfamily 0, groupB, member 2, patients, phytosterol, phytosterols, primary mouse hepatocytes, proinflammatory interleukin-1 beta, small interfering RNA, sodium, sulfate
ATP Binding Cassette Transporter, Subfamily G, Member 5, ATP Binding Cassette Transporter, Subfamily G, Member 8, Animals, Cholestasis, Chromatin Immunoprecipitation, Disease Models, Animal, Gas Chromatography-Mass Spectrometry, Gene Knockdown Techniques, Hep G2 Cells, Humans, Lipoproteins, Mice, Mice, Inbred C57BL, NF-kappa B, Parenteral Nutrition, Phytosterols, Receptors, Cytoplasmic and Nuclear
Author NameAffiliation
Swati GhoshUniversity of Colorado School of Medicine
Swati GhoshDigestive Health Institute, Children's Hospital Colorado
Michael W DevereauxUniversity of Colorado School of Medicine
Michael W DevereauxDigestive Health Institute, Children's Hospital Colorado
Aimee L AndersonUniversity of Colorado School of Medicine
Aimee L AndersonDigestive Health Institute, Children's Hospital Colorado
Sarah GehrkeUniversity of Colorado School of Medicine
Julie A ReiszUniversity of Colorado School of Medicine
Angelo D'AlessandroUniversity of Colorado School of Medicine
Angelo D'AlessandroUniversity of Colorado School of Medicine
David J OrlickyUniversity of Colorado School of Medicine
Mark A LovellUniversity of Colorado School of Medicine
Mark A LovellChildren's Hospital Colorado
Karim C El KasmiUniversity of Colorado School of Medicine
Colin T ShearnUniversity of Colorado School of Medicine
Ronald J SokolUniversity of Colorado School of Medicine
Ronald J SokolDigestive Health Institute, Children's Hospital Colorado
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