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Paper Details

Cell type-specific genetic regulation of gene expression across human tissues.
Science
172
2020
GTEx, QTLs, cell type-interaction QTLs, cell types, cis-, colocalized loci, eQTLs, expression QTLs, genes, human, quantitative trait loci
Author NameAffiliation
Sarah Kim-HellmuthMax Planck Institute of Psychiatry
Sarah Kim-HellmuthColumbia University
Sarah Kim-Hellmuth
François AguetThe Broad Institute of MIT and Harvard
Meritxell OlivaUniversity of Chicago
Meritxell OlivaUniversity of Chicago
Manuel Muñoz-AguirreThe Barcelona Institute for Science and Technology
Manuel Muñoz-AguirreUniversitat Politecnica de Catalunya (UPC)
Silva Kasela
Silva KaselaColumbia University
Valentin WucherThe Barcelona Institute for Science and Technology
Stephane E Castel
Stephane E CastelColumbia University
Andrew R HamelThe Broad Institute of MIT and Harvard
Andrew R HamelOcular Genomics Institute, Harvard Medical School
Ana ViñuelaKing's College London
Ana Viñuela
Ana ViñuelaInstitute for Genetics and Genomics in Geneva (iGE3), University of Geneva
Ana ViñuelaUniversity of Geneva Medical School
Amy L RobertsKing's College London
Serghei MangulUniversity of California los angeles
Serghei MangulSchool of Pharmacy, University of Southern California
Serghei MangulUniversity of California los angeles
Serghei MangulSchool of Pharmacy, University of Southern California
Xiaoquan WenUniversity of Michigan ann arbor
Gao WangUniversity of Chicago
Alvaro N BarbeiraUniversity of Chicago
Diego Garrido-MartínThe Barcelona Institute for Science and Technology
Brian B NadelUniversity of California los angeles
Yuxin ZouUniversity of Chicago
Rodrigo BonazzolaUniversity of Chicago
Jie Quan
Andrew A BrownUniversity of Geneva Medical School
Andrew A BrownUniversity of Dundee
Angel Martinez-PerezInstitut d'Investigacio Biomedica Sant Pau (IIB-Sant Pau)
José Manuel SoriaInstitut d'Investigacio Biomedica Sant Pau (IIB-Sant Pau)
Gad GetzThe Broad Institute of MIT and Harvard
Gad GetzHarvard Medical School
Gad GetzCancer Center and Department of Pathology, Massachusetts General Hospital
Gad GetzThe Broad Institute of MIT and Harvard
Gad GetzCancer Center and Department of Pathology, Massachusetts General Hospital
Gad GetzHarvard Medical School
Emmanouil T DermitzakisUniversity of Geneva Medical School
Emmanouil T Dermitzakis
Emmanouil T DermitzakisInstitute for Genetics and Genomics in Geneva (iGE3), University of Geneva
Emmanouil T DermitzakisUniversity of Geneva Medical School
Emmanouil T DermitzakisInstitute for Genetics and Genomics in Geneva (iGE3), University of Geneva
Emmanouil T Dermitzakis
Kerrin S SmallKing's College London
Matthew StephensUniversity of Chicago
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Datasets

GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link
GTExThe Genotype-Tissue Expression (GTEx) project aims to provide to the scientific community a resource with which to study human gene expression and regulation and its relationship to genetic variation. This project collected and analyzed multiple human tissues from donors who are also densely genotyped, to assess genetic variation within their genomes. By analyzing global RNA expression within individual tissues and treating the expression levels of genes as quantitative traits, variations in gene expression that are highly correlated with genetic variation can be identified as expression quantitative trait loci, or eQTLs.Link