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Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons.
mBio
39
2022
ACE2, Astrocyte, Astrocytes, CNS deficits, COVID-19, Coronavirus disease 2019, Dysfunction and Death of Neurons, IFN, Neuropilin-1, SARS, SARS-, SARS-CoV, SARS-CoV-2, TPC2, acute psychosis, acute respiratory syndrome coronavirus, angiotensin-converting enzyme 2, astrocytes, choline, delirium, genes, headache, human, induced pluripotent stem cell (iPSC)-derived brain organoids, inflammation, loss of smell and taste, neurological deficits, neuronal cell death, neuropilin-1, primary human astrocytes, reactive astrogliosis, seizures, stroke, systemic inflammation, two-pore segment channel 2, type I interferon, uninfected bystander neurons
Author NameAffiliation
Mauricio MontanoMichael Hulton Center for HIV Cure Research at Gladstone
Mauricio MontanoGladstone Institute of Virology
Xiaoyu LuoMichael Hulton Center for HIV Cure Research at Gladstone
Xiaoyu LuoGladstone Institute of Virology
Loic A Royer
Loic A Royer
Nadia R RoanMichael Hulton Center for HIV Cure Research at Gladstone
Nadia R RoanGladstone Institute of Virology
Nadia R RoanUniversity of California san francisco
Melanie OttMichael Hulton Center for HIV Cure Research at Gladstone
Melanie OttGladstone Institute of Virology
Melanie OttUniversity of California san francisco
Melanie OttUniversity of California san francisco
Warner C GreeneMichael Hulton Center for HIV Cure Research at Gladstone
Warner C GreeneGladstone Institute of Virology
Warner C GreeneUniversity of California san francisco
Warner C GreeneUniversity of California san francisco
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