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Paper Details

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.
N Engl J Med
525
2017
ANGPTL3, Angptl3, Cardiovascular Disease, HDL, LDL cholesterol, angiopoietin-like 3 gene, atherosclerotic cardiovascular disease, atherosclerotic lesion, cholesterol, coronary artery disease, dyslipidemic, evinacumab, exons, high-density lipoprotein (HDL) cholesterol, human, humans, lipoprotein (LDL) cholesterol, mice, participants, patients, triglyceride, triglycerides
Author NameAffiliation
Frederick E DeweyA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Viktoria GusarovaA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Colm O'DushlaineA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Claudia SchurmannA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Omri GottesmanA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Omri GottesmanA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Shane McCarthyA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Shane McCarthyA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Cristopher V Van HoutA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Shannon BruseA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Joseph B LeaderA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Michael F MurrayA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Michael F MurrayA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Marylyn D RitchieA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Marylyn D RitchieA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Helena KirchnerA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Helena KirchnerA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Lukas HabeggerA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Alexander LopezA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
John PennA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Andrew J MurphyA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Wayne Huey-Herng SheuA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
I-Te LeeA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Xiuqing GuoA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Jerome I RotterA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Yii-Der Ida ChenA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
William E KrausA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
William E KrausA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Svati H ShahA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Svati H ShahA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Scott M DamrauerA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Scott M DamrauerA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Aeron M SmallA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Daniel J RaderA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Anders B WulffA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Børge G NordestgaardA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Anne Tybjaerg-HansenA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
David H LedbetterA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
David H LedbetterA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
David J CareyA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
David J CareyA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
John D OvertonA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
John D OvertonA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Jeffrey G ReidA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Jeffrey G ReidA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Alan R ShuldinerA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Alan R ShuldinerA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Ingrid B BoreckiA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
Tanya M TeslovichA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
George D YancopoulosA. Baras) and Regeneron Pharmaceuticals (V.G., Perelman School of Medicine, University of Pennsylvania, Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), Chung Shan Medical University (I.-T.L.), China Medical University (K.-W.L.), and School of Medicine, National Yang-Ming University (W.H.H.S., National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-university of california los angeles Medical Center, Molecular Physiology Institute, Duke University, Rigshospitalet (A.B.W., Herlev and Gentofte Hospital, Frederiksberg Hospital, Copenhagen University Hospital, University of Copenhagen (B.G.N.
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link