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Paper Details

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.
Nature
11
2024
CD8, Dupilumab, IL-4, IL-4 receptor, IL-4R, Myeloid cells, NSCLC, PD-1, PD-L1, basophils, bone marrow basophils, cancer, circulating monocytes, early myeloid progenitors, eosinophils, granulocyte-monocyte progenitors, human, humans, immunosuppressive, immunosuppressive myeloid cell states, interleukin-4, mature myeloid cells, mice, mouse, non-small cell lung cancer, patients, single-cell RNA, systemic malady, tumour, tumour-infiltrating CD8 T cells, tumour-infiltrating monocyte-derived macrophage, tumour-infiltrating monocyte-derived macrophage phenotype, tumour-promoting myeloid cells
Author NameAffiliation
Florent Ginhoux
Florent GinhouxSingHealth Duke-NUS Academic Medical Centre, Translational Immunology Institute
Florent GinhouxShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine
Florent GinhouxINSERM U5
Sacha GnjaticMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Sacha GnjaticIcahn School of Medicine at Mount Sinai
Sacha GnjaticIcahn School of Medicine at Mount Sinai
Sacha GnjaticIcahn School of Medicine at Mount Sinai
Sacha GnjaticThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Sacha GnjaticMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Sacha GnjaticThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Sacha GnjaticIcahn School of Medicine at Mount Sinai
Sacha GnjaticIcahn School of Medicine at Mount Sinai
Sacha GnjaticIcahn School of Medicine at Mount Sinai
Seunghee Kim-SchulzeMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Seunghee Kim-SchulzeIcahn School of Medicine at Mount Sinai
Seunghee Kim-SchulzeMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Seunghee Kim-SchulzeIcahn School of Medicine at Mount Sinai
Brian D BrownMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Brian D BrownIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai
Brian D BrownIcahn School of Medicine at Mount Sinai
Brian D BrownThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Miriam MeradMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Miriam MeradThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Miriam MeradIcahn School of Medicine at Mount Sinai
Miriam MeradIcahn School of Medicine at Mount Sinai
Miriam MeradCenter for Thoracic Oncology, Icahn School of Medicine at Mount Sinai
Miriam MeradIcahn School of Medicine at Mount Sinai
Miriam MeradMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Miriam MeradThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Miriam MeradIcahn School of Medicine at Mount Sinai
Miriam MeradIcahn School of Medicine at Mount Sinai
Miriam MeradCenter for Thoracic Oncology, Icahn School of Medicine at Mount Sinai
Miriam MeradIcahn School of Medicine at Mount Sinai
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ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link