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Paper Details

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.
Sci Transl Med
33
2020
CRC, CRC lineage, Colorectal cancer, EGFR, EGFR-activating ligands, HER antibodies, HER2, HER3, PDX models, PI3K, Paneth, Paneth cell, Paneth cell-like phenotype, YAP, Yes-associated protein, epidermal growth factor receptor, genes, human, human epidermal growth factor receptor 2, intestinal secretory precursors, lingering tumors, mCRC, mCRC cells, metastatic colorectal cancer, patient, patients, phosphatidylinositol, phosphatidylinositol 3-kinase, pseudodifferentiated, pseudodifferentiated tumor remnants, quiescent, quiescent subpopulation of normal, residual disease cells, tumor, tumors
Author NameAffiliation
Francesco GalimiUniversity of Torino
Francesco GalimiCandiolo Cancer Institute-FPO IRCCS
Enzo MedicoUniversity of Torino
Enzo MedicoCandiolo Cancer Institute-FPO IRCCS
Andrea SottorivaThe Institute of Cancer Research
Rodrigo DienstmannVall d'Hebron Institute of Oncology (VHIO)
Diego PasiniEuropean Institute of Oncology IRCCS
Diego PasiniUniversity of Milano
Andrea BertottiUniversity of Torino
Andrea BertottiCandiolo Cancer Institute-FPO IRCCS
Livio TrusolinoUniversity of Torino
Livio TrusolinoCandiolo Cancer Institute-FPO IRCCS
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