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Paper Details

Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice.
J Mol Med (Berl)
30
2020
-, AH, AH-HC, AH-HMs, ALD, Col1a1, EVs, Extracellular vesicles, HC, HC-EVs, HMs, HSC, HSCs, IL-, IL-1, IL-17, Nr1d2, Nr1d2 genes, Smad7, Smad7 and Nr1d2 genes, TLR9, alcoholic hepatitis, alcoholic liver disease, circulating, hepatic macrophages, hepatic stellate cells, hepatocyte, human, miR, miR-, miR-27a, miRNA, miRNAs, mice, mitochondrial DNA, murine, murine primary hepatic stellate cells, patients, quiescent HSC
Animals, DNA, Mitochondrial, Down-Regulation, Extracellular Vesicles, Hepatic Stellate Cells, Hepatitis, Alcoholic, Hepatocytes, Humans, Interleukin-17, Interleukin-1beta, Liver, Macrophages, Male, Mice, Mice, Inbred C57BL, MicroRNAs, Up-Regulation
Author NameAffiliation
Akiko EguchiGraduate School of Medicine, Mie University
Akiko EguchiUniversity of California San Diego
Akiko EguchiSouthern California Research Center for ALPD and Cirrhosis
Akiko Eguchi
Rui YanSouthern California Research Center for ALPD and Cirrhosis
Rui YanKeck School of Medicine of the University of Southern California
Stephanie Q PanSouthern California Research Center for ALPD and Cirrhosis
Stephanie Q PanKeck School of Medicine of the University of Southern California
Raymond WuSouthern California Research Center for ALPD and Cirrhosis
Raymond WuKeck School of Medicine of the University of Southern California
Jihoon KimUniversity of California San Diego
Yibu ChenKeck School of Medicine of the University of Southern California
Charles AnsongPacific Northwest National Laboratory
Richard D SmithPacific Northwest National Laboratory
Richard D SmithPacific Northwest National Laboratory
Mina TempakuGraduate School of Medicine, Mie University
Lucila Ohno-MachadoUniversity of California San Diego
Lucila Ohno-MachadoUniversity of California San Diego
Yoshiyuki TakeiGraduate School of Medicine, Mie University
Ariel E FeldsteinUniversity of California San Diego
Ariel E FeldsteinSouthern California Research Center for ALPD and Cirrhosis
Hidekazu TsukamotoSouthern California Research Center for ALPD and Cirrhosis
Hidekazu TsukamotoKeck School of Medicine of the University of Southern California
Hidekazu TsukamotoGreater Los Angeles VA Healthcare System
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