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Paper Details

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
EBioMedicine
1
2023
DS, DYRK1A, DYRK1A kinase, Down syndrome, Human, IgG-glycans, LaminB1, People, cerebral organoids, chromosome-21 gene, full and partial trisomy-21, genes, hiPSC, hiPSCs, human, human induced pluripotent stem cell, isogenic hiPSC models, nucleated blood cells, over-acting genes, plasma immunoglobulin-G, progeroid, progeroid syndrome, sugar, supernumerary chromosome, supernumerary chromosome-21 genes
Author NameAffiliation
Yuin-Han LohInstitute of Molecular and Cell Biology (IMCB)
Tim D SpectorKing's College London
Tim D SpectorKing's College London
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Release 1.2