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Author Details

Milton H Werner
Inhibikase Therapeutics Inc.
1991
44
25
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36652533The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.Sci Transl Med2023
34816484Parkinson's Disease Modification Through Abl Kinase Inhibition: An Opportunity.Mov Disord2022
33221532Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.Neurobiol Dis2021
34561166Seeking progress in disease modification in Parkinson disease.Parkinsonism Relat Disord2021
30514402Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents.BMC Pharmacol Toxicol2018
27198748Natalizumab-treated patients at high risk for PML persistently excrete JC polyomavirus.J Neurovirol2016
24218989Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.Pharm Dev Technol2015
18485078A basic/hydrophobic cleft of the T4 activator MotA interacts with the C-terminus of E.coli sigma70 to activate middle gene transcription.Mol Microbiol2008
18790797Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.Haematologica2008
17436447NIH funding: what does the future look like?Science2007
17572682A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.Nat Struct Mol Biol2007
16247445ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.Oncogene2006
17102623Emerging roles for the death adaptor FADD in death receptor avidity and cell cycle regulation.Cell Cycle2006
16762833The structure of FADD and its mode of interaction with procaspase-8.Mol Cell2006
16791737iDC: A comprehensive toolkit for the analysis of residual dipolar couplings for macromolecular structure determination.J Biomol NMR2006
16710361FADD self-association is required for stable interaction with an activated death receptor.Cell Death Differ2006
16006552A mechanism for death receptor discrimination by death adaptors.J Biol Chem2005
14573612Identification of an expanded binding surface on the FADD death domain responsible for interaction with CD95/Fas.J Biol Chem2004
15257291T4 AsiA blocks DNA recognition by remodeling sigma70 region 4.EMBO J2004
15377655The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.J Biol Chem2004
14506247PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.J Biol Chem2003
14712671Molecular analysis of activator engagement with RNA polymerase.Methods Enzymol2003
12456656Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain.EMBO J2002
11460553Uniform 13C/15N-labeling of DNA by tandem repeat amplification.Methods Enzymol2001
11327761Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain.J Mol Biol2001
11742991Flipping a genetic switch by subunit exchange.EMBO J2001
10581073Runt domains take the lead in hematopoiesis and osteogenesis.Nat Med1999
10404215Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta.Nat Struct Biol1999
10404214Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.Nat Struct Biol1999
9689043Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly.Proc Natl Acad Sci U S A1998
9460239Correction of the NMR structure of the ETS1/DNA complex.J Biomol NMR1997
9221491ETS1-DNA binding and intercalation: correction.Science1997
9118214Architectural transcription factors: proteins that remodel DNA.Cell1997
8628992Intercalation, DNA kinking, and the control of transcription.Science1996
8772384Molecular determinants of mammmalian sex.Trends Biochem Sci1996
8805578Stopping death cold.Structure1996
7547937NMR spectroscopic analysis of the DNA conformation induced by the human testis determining factor SRY.Biochemistry1995
8521493The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation.Cell1995
7774012Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex.Cell1995
7922368Symmetry and asymmetry in the function of Escherichia coli integration host factor: implications for target identification by DNA-binding proteins.Curr Biol1994
8200443Refolding proteins by gel filtration chromatography.FEBS Lett1994
1602487Identification of a protein-binding surface by differential amide hydrogen-exchange measurements. Application to Bowman-Birk serine-protease inhibitor.J Mol Biol1992
1734975Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution.Biochemistry1992
20128011H assignments and secondary structure determination of the soybean trypsin/chymotrypsin Bowman-Birk inhibitor.Biochemistry1991
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Collaborators

Angela M Gronenborn
University of Pittsburgh
Co-authored papers 9
Vineet Gupta
Purdue University
Co-authored papers 3
Takashi Nagata
Institute of Advanced Energy, Kyoto University
Co-authored papers 3
Yoshiaki Ito
Tokyo Medical and Dental University (TMDU)
Co-authored papers 3
Katsuya Shigesada
Institute for Virus Research, Kyoto University
Co-authored papers 3
Mark H Ginsberg
University of California
Co-authored papers 2
Evripidis Gavathiotis
Albert Einstein College of Medicine
Co-authored papers 2
Ted M Dawson
Johns Hopkins University School of Medicine
Co-authored papers 2
Woo Young Kim
Westchester Medical Center
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Stephen K Burley
The State University of New Jersey
Co-authored papers 1
Michael A Schwarzschild
Co-authored papers 1
Nina F Schor
National Institute of Neurological Disorders and Stroke
Co-authored papers 1
Stefan Burdach
Technische Universitat Munchen
Co-authored papers 1
Jeffrey H Kordower
ASU-Banner Neurodegenerative Disease Research Center, Arizona State University
Co-authored papers 1
Shigeyuki Yokoyama
Shinshu University School of Medicine
Co-authored papers 1
Brian T Chait
The Rockefeller University
Co-authored papers 1
Caroline M Groft
The Rockefeller University
Co-authored papers 1
Valina L Dawson
Institute for Cell Engineering, Johns Hopkins University School of Medicine
Co-authored papers 1
D Sorce
Co-authored papers 1
Torsten Haferlach
Taussig Cancer Institute, Cleveland Clinic
Co-authored papers 1
Rong Wang
Co-authored papers 1
Release 1.2