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Author Details

David V Schaffer
University of California berkeley
1994
246
74
PMIDPaper TitleJournal TitlePublished Year
37401411Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture.Development2023
37216516Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases.Proc Natl Acad Sci U S A2023
35273478Optogenetic Application to Investigating Cell Behavior and Neurological Disease.Front Cell Neurosci2022
35427160<i>Egr1</i> is a 3D matrix-specific mediator of mechanosensitive stem cell lineage commitment.Sci Adv2022
37073402In vivo hypermutation and continuous evolution.Nat Rev Methods Primers2022
36516094The Coming of Age of Topical Gene Therapy for Dystrophic Epidermolysis Bullosa.N Engl J Med2022
36147944A scalable and tunable thermoreversible polymer for 3D human pluripotent stem cell biomanufacturing.iScience2022
36173188Apodization Specific Fitting for Improved Resolution, Charge Measurement, and Data Analysis Speed in Charge Detection Mass Spectrometry.J Am Soc Mass Spectrom2022
35961005Effects of Molecular Size on Resolution in Charge Detection Mass Spectrometry.Anal Chem2022
35926780A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation.Acta Biomater2022
34028263Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell-ECM Interactions.ACS Biomater Sci Eng2021
33720126Simple, Affordable, and Modular Patterning of Cells using DNA.J Vis Exp2021
33895085Adeno-Associated Virus Vector for Central Nervous System Gene Therapy.Trends Mol Med2021
33750112High-Throughput Discovery of Targeted, Minimally Complex Peptide Surfaces for Human Pluripotent Stem Cell Culture.ACS Biomater Sci Eng2021
34664552scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution.Elife2021
34513296Genome-wide activation screens to increase adeno-associated virus production.Mol Ther Nucleic Acids2021
32485105Targeted Diversification in the <i>S. cerevisiae</i> Genome with CRISPR-Guided DNA Polymerase I.ACS Synth Biol2020
33510596Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy.Adv Funct Mater2020
31940260Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells.Mol Biol Cell2020
33377035Protocol to Fabricate Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics.STAR Protoc2020
33139571β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells.Proc Natl Acad Sci U S A2020
32601435The delivery challenge: fulfilling the promise of therapeutic genome editing.Nat Biotechnol2020
32799685Novel Lung Tropic Adeno-Associated Virus Capsids for Therapeutic Gene Delivery.Hum Gene Ther2020
32794731CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics.ACS Synth Biol2020
32821815High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates.Sci Adv2020
32119023One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway.Chem Commun (Camb)2020
32521262Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics.Cell Rep2020
32206713Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach.Sci Adv2020
32271719In vivo-directed evolution of adeno-associated virus in the primate retina.JCI Insight2020
31103526Engineering biomaterials to control the neural differentiation of stem cells.Brain Res Bull2019
31670142AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems.Mol Ther Nucleic Acids2019
30102775High-throughput combinatorial screening reveals interactions between signaling molecules that regulate adult neural stem cell fate.Biotechnol Bioeng2019
30229860High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture.Biotechnol Bioeng2019
31242412CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection.Cell Rep2019
31465962CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model.Mol Ther Nucleic Acids2019
31634414Gene Editing to Generate Versatile Human Pluripotent Stem Cell Reporter Lines for Analysis of Differentiation and Lineage Tracing.Stem Cells2019
31332317Mastering their own fates through the matrix.Nat Mater2019
30807882Engineering the AAV capsid to evade immune responses.Curr Opin Biotechnol2019
29188518Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas.Methods Mol Biol2018
34046535Adeno-associated virus-mediated delivery of CRISPR-Cas9 for genome editing in the central nervous system.Curr Opin Biomed Eng2018
30240607Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics.iScience2018
30075851Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation.Biophys J2018
30069054CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window.Nature2018
29874625Proliferation versus Differentiation: Redefining Retinoic Acid's Role.Stem Cell Reports2018
30089262The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage.Cell Rep2018
30196036Corrigendum to "Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits" [Curr. Opin. Neurobiol. 50 (2018) 163-170].Curr Opin Neurobiol2018
31015716Cheaper and less variable expansion.Nat Biomed Eng2018
29614429Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits.Curr Opin Neurobiol2018
29717823Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture.Adv Healthc Mater2018
29628395hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.Stem Cell Reports2018
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Collaborators

Lawrence Berkeley National Laboratory
Co-authored papers 13
University of California davis
Co-authored papers 9
Mayo Clinic
Co-authored papers 6
Massachusetts Institute of Technology
Co-authored papers 4
University of California Santa Barbara
Co-authored papers 4
Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes
Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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The University of Hong Kong
Co-authored papers 1
Skidmore College
Co-authored papers 1
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Co-authored papers 1
Gladstone Institute of Cardiovascular Disease
Co-authored papers 1
Boston University
Co-authored papers 1
University Health Network, University Health Network and University of Toronto
Co-authored papers 1
Stanford University
Co-authored papers 1
Mayo Clinic
Co-authored papers 1
Co-authored papers 1
Howard Hughes Medical Institute
Co-authored papers 1
University of California berkeley
Co-authored papers 1
Joint BioEnergy Institute
Co-authored papers 1
Co-authored papers 1
School of Pharmaceutical Sciences, Xiamen University
Co-authored papers 1
University of California berkeley
Co-authored papers 1
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E O Lawrence Berkeley National Laboratory, UCSF Medical Center, University of California, Berkeley, University of Chicago
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University of California irvine
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Vanderbilt University Medical Center
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University of California berkeley
Co-authored papers 1